Madd MAP-kinase activating death domain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maddprovided by RGD
Official Full Name: MAP-kinase activating death domainprovided by RGD
Primary source: RGD:619922
See related: Ensembl:ENSRNOG00000012568 AllianceGenome:RGD:619922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RabGEF; RabGEP
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in cytosol; nucleus; and synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 155.6), Spleen (RPKM 101.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (97570141..97613688, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (77114330..77157865, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (79960301..80003023, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicated that Madd functions as a guanine nucleotide exchange factor for Rab27 in parotid acinar cells and regulates isoproterenol-stimulated amylase release.
Title: MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE102504 (e-PCR)
- UniSTS:244228

PMC33205P3 (e-PCR)
- UniSTS:273158

AI548269 (e-PCR)
- UniSTS:243509

STS-U22662 (e-PCR)
- UniSTS:66401

D3Wox32 (e-PCR)
- UniSTS:240529

RH139546 (e-PCR)
- UniSTS:221631

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of pancreatic amylase secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rab protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rab protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MAP kinase-activating death domain protein

Names: Rab3 GDP/GTP exchange protein; rab3 GDP/GTP exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429606.1 → NP_001416535.1 MAP kinase-activating death domain protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A7E5, A0A8L2Q8M9
NM_001429607.1 → NP_001416536.1 MAP kinase-activating death domain protein isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZSL5, A0A8L2Q8M9
NM_001429608.1 → NP_001416537.1 MAP kinase-activating death domain protein isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTV3
NM_001429609.1 → NP_001416538.1 MAP kinase-activating death domain protein isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2Q8M9
NM_001429610.1 → NP_001416539.1 MAP kinase-activating death domain protein isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2Q8M9
NM_001429611.1 → NP_001416540.1 MAP kinase-activating death domain protein isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTV3
NM_001429612.1 → NP_001416541.1 MAP kinase-activating death domain protein isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2Q8M9
NM_001429613.1 → NP_001416542.1 MAP kinase-activating death domain protein isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2KA27, A0A8I5ZTV3
NM_001429614.1 → NP_001416543.1 MAP kinase-activating death domain protein isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2Q8M9
NM_053585.3 → NP_446037.1 MAP kinase-activating death domain protein isoform 1

See identical proteins and their annotated locations for NP_446037.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O08873

UniProtKB/TrEMBL

A0A8L2Q8M9, A6HNA9

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

97570141..97613688 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284778.1 → XP_063140848.1 MAP kinase-activating death domain protein isoform X32
XM_063284754.1 → XP_063140824.1 MAP kinase-activating death domain protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284759.1 → XP_063140829.1 MAP kinase-activating death domain protein isoform X7

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284757.1 → XP_063140827.1 MAP kinase-activating death domain protein isoform X5

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284765.1 → XP_063140835.1 MAP kinase-activating death domain protein isoform X13

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284755.1 → XP_063140825.1 MAP kinase-activating death domain protein isoform X3

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284751.1 → XP_063140821.1 MAP kinase-activating death domain protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284764.1 → XP_063140834.1 MAP kinase-activating death domain protein isoform X12

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284758.1 → XP_063140828.1 MAP kinase-activating death domain protein isoform X6

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284762.1 → XP_063140832.1 MAP kinase-activating death domain protein isoform X10

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284767.1 → XP_063140837.1 MAP kinase-activating death domain protein isoform X16

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284756.1 → XP_063140826.1 MAP kinase-activating death domain protein isoform X4

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284760.1 → XP_063140830.1 MAP kinase-activating death domain protein isoform X8

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284776.1 → XP_063140846.1 MAP kinase-activating death domain protein isoform X28

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284772.1 → XP_063140842.1 MAP kinase-activating death domain protein isoform X24

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284766.1 → XP_063140836.1 MAP kinase-activating death domain protein isoform X15

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284771.1 → XP_063140841.1 MAP kinase-activating death domain protein isoform X23

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_039106011.2 → XP_038961939.1 MAP kinase-activating death domain protein isoform X14

UniProtKB/TrEMBL

A0A8I5ZTV3

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
XM_063284763.1 → XP_063140833.1 MAP kinase-activating death domain protein isoform X11

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_039106022.2 → XP_038961950.1 MAP kinase-activating death domain protein isoform X22

UniProtKB/TrEMBL

A0A8L2Q8M9

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
XM_039106019.2 → XP_038961947.1 MAP kinase-activating death domain protein isoform X19

UniProtKB/TrEMBL

A0A8L2Q8M9

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
XM_039106028.2 → XP_038961956.1 MAP kinase-activating death domain protein isoform X29

UniProtKB/TrEMBL

A0A8I5ZTV3

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
XM_039106021.2 → XP_038961949.1 MAP kinase-activating death domain protein isoform X21

UniProtKB/TrEMBL

A0A8I5ZTV3

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
XM_063284770.1 → XP_063140840.1 MAP kinase-activating death domain protein isoform X20

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284761.1 → XP_063140831.1 MAP kinase-activating death domain protein isoform X9
XM_039106031.2 → XP_038961959.1 MAP kinase-activating death domain protein isoform X31

UniProtKB/TrEMBL

A0A8L2Q8M9

Conserved Domains (3) summary

smart00801
Location:485 → 553

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:172 → 401

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:7 → 97

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
XM_063284777.1 → XP_063140847.1 MAP kinase-activating death domain protein isoform X30
XM_063284773.1 → XP_063140843.1 MAP kinase-activating death domain protein isoform X25
XM_063284775.1 → XP_063140845.1 MAP kinase-activating death domain protein isoform X27

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284793.1 → XP_063140863.1 MAP kinase-activating death domain protein isoform X47

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284774.1 → XP_063140844.1 MAP kinase-activating death domain protein isoform X26
XM_063284768.1 → XP_063140838.1 MAP kinase-activating death domain protein isoform X17

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284753.1 → XP_063140823.1 MAP kinase-activating death domain protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284752.1 → XP_063140822.1 MAP kinase-activating death domain protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284769.1 → XP_063140839.1 MAP kinase-activating death domain protein isoform X18

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284792.1 → XP_063140862.1 MAP kinase-activating death domain protein isoform X46
XM_063284781.1 → XP_063140851.1 MAP kinase-activating death domain protein isoform X35

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284780.1 → XP_063140850.1 MAP kinase-activating death domain protein isoform X34

UniProtKB/TrEMBL

A0A8I5Y5V9, A0A8I5ZTV3
XM_063284787.1 → XP_063140857.1 MAP kinase-activating death domain protein isoform X41

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284785.1 → XP_063140855.1 MAP kinase-activating death domain protein isoform X39

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284786.1 → XP_063140856.1 MAP kinase-activating death domain protein isoform X40

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284783.1 → XP_063140853.1 MAP kinase-activating death domain protein isoform X37

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284779.1 → XP_063140849.1 MAP kinase-activating death domain protein isoform X33

UniProtKB/TrEMBL

A0A8I5ZTV3
XM_063284790.1 → XP_063140860.1 MAP kinase-activating death domain protein isoform X44
XM_063284789.1 → XP_063140859.1 MAP kinase-activating death domain protein isoform X43

UniProtKB/TrEMBL

A0A8L2Q8M9
XM_063284788.1 → XP_063140858.1 MAP kinase-activating death domain protein isoform X42
XM_063284784.1 → XP_063140854.1 MAP kinase-activating death domain protein isoform X38
XM_063284782.1 → XP_063140852.1 MAP kinase-activating death domain protein isoform X36
XM_063284791.1 → XP_063140861.1 MAP kinase-activating death domain protein isoform X45

UniProtKB/TrEMBL

A0A8L2Q8M9