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    Ppp1r12c protein phosphatase 1, regulatory subunit 12C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499076, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Ppp1r12cprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Cprovided by RGD
    Primary source
    RGD:1584883
    See related
    Ensembl:ENSRNOG00000053828 AllianceGenome:RGD:1584883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to be involved in negative regulation of catalytic activity and signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PPP1R12C (protein phosphatase 1 regulatory subunit 12C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 212.5), Heart (RPKM 208.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r12c in Genome Data Viewer
    Location:
    1q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78362900..78385873)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69320240..69343200)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72903139..72926108)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin I3, cardiac type Neighboring gene troponin T1, slow skeletal type Neighboring gene EPS8-like 1 Neighboring gene retinol dehydrogenase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 12C
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 12C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191946.2 → NP_001178875.2  protein phosphatase 1 regulatory subunit 12C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K4R1, A6KNL5
      Related
      ENSRNOP00000073139.1, ENSRNOT00000086122.2
      Conserved Domains (5) summary
      cd00204
      Location:99 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:109 → 261
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:264 → 312
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:685 → 783
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:104 → 135
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78362900..78385873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758961.3 → XP_008757183.1  protein phosphatase 1 regulatory subunit 12C isoform X1

      UniProtKB/TrEMBL
      A6KNL5
      Conserved Domains (5) summary
      cd00204
      Location:99 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:109 → 261
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:264 → 312
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:684 → 782
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:104 → 135
      ANK; ANK repeat [structural motif]

    2. XM_017589553.3 → XP_017445042.1  protein phosphatase 1 regulatory subunit 12C isoform X2

    3. XM_063270835.1 → XP_063126905.1  protein phosphatase 1 regulatory subunit 12C isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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