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    Zxdc ZXD family zinc finger C [ Mus musculus (house mouse) ]

    Gene ID: 80292, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zxdcprovided by MGI
    Official Full Name
    ZXD family zinc finger Cprovided by MGI
    Primary source
    MGI:MGI:1933108
    See related
    Ensembl:ENSMUSG00000034430 AllianceGenome:MGI:1933108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930012H20; B930086F11Rik
    Summary
    Predicted to enable C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and gonad. Orthologous to human ZXDC (ZXD family zinc finger C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.4), adrenal adult (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 D1; 6 40.16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90346460..90380472)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90369478..90403490)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene urocanase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene cilia and flagella associated protein 100 Neighboring gene predicted gene, 53295 Neighboring gene STARR-seq mESC enhancer starr_16619 Neighboring gene Kruppel-like transcription factor 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-fate transition and determination analysis of mouse male germ cells throughout development. Zhao J, et al. Nat Commun, 2021 Nov 25. PMID 34824237, Free PMC Article
    2. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein ZXDC

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030260.3 → NP_084536.2  zinc finger protein ZXDC isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter protein (isoform 1).
      Source sequence(s)
      AC163346, AK042190, AK044429, AK081005
      Consensus CDS
      CCDS51848.1
      UniProtKB/Swiss-Prot
      Q8C8V1
      Related
      ENSMUSP00000109167.3, ENSMUST00000113539.8
      Conserved Domains (4) summary
      COG5048
      Location:392 → 691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:226 → 252
      zf-H2C2_2; Zinc-finger double domain
      pfam17017
      Location:209 → 354
      zf-C2H2_aberr; Aberrant zinc-finger

    2. NM_173002.3 → NP_766590.1  zinc finger protein ZXDC isoform 2

      See identical proteins and their annotated locations for NP_766590.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has additional exons in the 3' coding region and UTR. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK044429, AK044529, AK081005
      Consensus CDS
      CCDS20358.1
      UniProtKB/Swiss-Prot
      Q3TEP2, Q3URC2, Q8C4U7, Q8C4Z9, Q8C8C2, Q8C8T1, Q8C8V1, Q99J65
      Related
      ENSMUSP00000074619.4, ENSMUST00000075117.10
      Conserved Domains (4) summary
      COG5048
      Location:176 → 363
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:334 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:376 → 402
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:241 → 318
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      90346460..90380472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_377502.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C8V1.1 GenPept UniProtKB/Swiss-Prot:Q8C8V1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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