PPP1CC protein phosphatase 1 catalytic subunit gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPP1CCprovided by HGNC
Official Full Name: protein phosphatase 1 catalytic subunit gammaprovided by HGNC
Primary source: HGNC:HGNC:9283
See related: Ensembl:ENSG00000186298 MIM:176914; AllianceGenome:HGNC:9283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP1C; PP-1G; PPP1G
Summary: The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression: Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (110708376..110742891, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (110686068..110720600, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (111157485..111180696, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation.
Title: TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation.
PP1gamma regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.
Title: PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Title: Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Title: Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Title: Structure of the MRAS-SHOC2-PP1C phosphatase complex.
The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
Title: The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
Aurora B regulates PP1gamma-Repo-Man interactions to maintain the chromosome condensation state.
Title: Aurora B regulates PP1γ-Repo-Man interactions to maintain the chromosome condensation state.
our work has identified both the mechanism of SLFN11 activation and PPP1CC as the enzyme responsible for its activation. Our findings open up future studies of the PPP1CC subunit(s) involved in SLFN11 activation and the putative kinase(s) that inactivates SLFN11.
Title: Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response.
Here the authors show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzymes are dynamically regulated by Aurora B kinase during mitosis.
Title: The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
Data suggest that PPP1CC catalyzes hydrolysis of an assortment of substrates (aryl methylphosphonates, fluorophosphate esters, phosphorothioate esters, phosphodiesters); conservative mutation of R221 to K results in a mutant that is more effective catalyst toward monoanionic substrates; PPP1CC does not catalyze the hydrolysis of a sulfate ester, which is unexpected.
Title: Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Small molecular compounds prevent the interaction of HIV-1 Tat with protein phosphatase-1 (PP1) and the shuttling of PP1 to the nucleus	PubMed
	tat	PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1	PubMed
	tat	Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9	PubMed
	tat	Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1	PubMed
	tat	Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1327 (e-PCR)
- UniSTS:68388

D12S2097 (e-PCR)
- UniSTS:71030

SHGC-62982 (e-PCR)
- UniSTS:95374

RH48038 (e-PCR)
- UniSTS:4541

NoName (e-PCR)
- UniSTS:76224

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables lamin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	TAS Traceable Author Statement more info
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	TAS Traceable Author Statement more info
involved_in blastocyst development	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Names: protein phosphatase 1, catalytic subunit, gamma isozyme; protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma

NP_001231903.1

EC 3.1.3.16

NP_002701.1

EC 3.1.3.16

XP_011536806.1

EC 3.1.3.16

XP_011536807.1

EC 3.1.3.16

XP_054228341.1

EC 3.1.3.16

XP_054228342.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030325.2 RefSeqGene

Range

5000..28211

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001244974.2 → NP_001231903.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2

See identical proteins and their annotated locations for NP_001231903.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a longer isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AA781342, AW575661, BC014073, DA514523

Consensus CDS

CCDS58279.1

UniProtKB/TrEMBL

Q9UPN1

Related

ENSP00000341779.5, ENST00000340766.9

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
NM_002710.4 → NP_002701.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

See identical proteins and their annotated locations for NP_002701.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

AC144522, AW575661, BC014073, DA514523, X74008

Consensus CDS

CCDS9150.1

UniProtKB/Swiss-Prot

P36873

UniProtKB/TrEMBL

Q9UPN1

Related

ENSP00000335084.5, ENST00000335007.10

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

110708376..110742891 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011538505.4 → XP_011536807.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2

UniProtKB/TrEMBL

Q9UPN1

Conserved Domains (2) summary

PTZ00480
Location:6 → 313

PTZ00480; serine/threonine-protein phosphatase; Provisional

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
XM_011538504.4 → XP_011536806.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1

UniProtKB/TrEMBL

Q9UPN1

Conserved Domains (2) summary

PTZ00480
Location:6 → 315

PTZ00480; serine/threonine-protein phosphatase; Provisional

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RNA

XR_007063094.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

110686068..110720600 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372367.1 → XP_054228342.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2
XM_054372366.1 → XP_054228341.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1