Lrrc32 leucine rich repeat containing 32 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc32provided by RGD
Official Full Name: leucine rich repeat containing 32provided by RGD
Primary source: RGD:1309087
See related: Ensembl:ENSRNOG00000015310 AllianceGenome:RGD:1309087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Garp
Summary: Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in regulation of transforming growth factor beta3 activation; secondary palate development; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within negative regulation of activated T cell proliferation; negative regulation of cytokine production; and positive regulation of gene expression. Predicted to be located in cell surface and nucleoplasm. Orthologous to human LRRC32 (leucine rich repeat containing 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 33.2), Lung (RPKM 30.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (162196995..162209563)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152785709..152802997)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163443972..163457426)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in establishment of protein localization to extracellular region	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming growth factor beta activator LRRC32

Names: glycoprotein A repetitions predominant; leucine-rich repeat-containing protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170434.3 → NP_001163905.1 transforming growth factor beta activator LRRC32 precursor

See identical proteins and their annotated locations for NP_001163905.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I6E0, D3ZVD5

Related

ENSRNOP00000020520.3, ENSRNOT00000020520.6

Conserved Domains (3) summary

PLN00113
Location:123 → 575

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:55 → 75

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:55 → 278

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

162196995..162209563

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229747.5 → XP_006229809.1 transforming growth factor beta activator LRRC32 isoform X2

See identical proteins and their annotated locations for XP_006229809.1

UniProtKB/TrEMBL

A6I6E0, D3ZVD5

Conserved Domains (3) summary

PLN00113
Location:123 → 575

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:55 → 75

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:55 → 278

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_063285048.1 → XP_063141118.1 transforming growth factor beta activator LRRC32 isoform X3
XM_039106013.2 → XP_038961941.1 transforming growth factor beta activator LRRC32 isoform X2

UniProtKB/TrEMBL

A6I6E0, D3ZVD5

Conserved Domains (3) summary

PLN00113
Location:123 → 575

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:55 → 75

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:55 → 278

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006229746.5 → XP_006229808.1 transforming growth factor beta activator LRRC32 isoform X1

UniProtKB/TrEMBL

A0A8I5ZYB9

Related

ENSRNOP00000083930.1

Conserved Domains (3) summary

cd00116
Location:82 → 305

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:82 → 102

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:177 → 237

LRR_8; Leucine rich repeat