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    Dock6 dedicator of cytokinesis 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367039, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dock6provided by RGD
    Official Full Name
    dedicator of cytokinesis 6provided by RGD
    Primary source
    RGD:1306517
    See related
    Ensembl:ENSRNOG00000010652 AllianceGenome:RGD:1306517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 80.9), Kidney (RPKM 47.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dock6 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28618523..28670741, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20342430..20394660, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22822412..22874670, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene angiopoietin-like 8 Neighboring gene uncharacterized LOC120094090 Neighboring gene RAB3D, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Chi HC, et al. Oncogene, 2020 Sep. PMID 32753649
    2. Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis. Zhang ZY, et al. Arch Oral Biol, 2022 Jan. PMID 34742001
    3. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies. Sukalo M, et al. Hum Mutat, 2015 Jun. PMID 25824905
    4. miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis. Li X, et al. J Exp Clin Cancer Res, 2018 Mar 27. PMID 29587866, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394344.1 → NP_001381273.1  dedicator of cytokinesis protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ANH8, D3ZY19
      Related
      ENSRNOP00000063161.2, ENSRNOT00000064551.3
      Conserved Domains (3) summary
      cd08696
      Location:547 → 724
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1658 → 2080
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    2. NM_001413911.1 → NP_001400840.1  dedicator of cytokinesis protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2KAH4
      Related
      ENSRNOP00000075398.2, ENSRNOT00000090424.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28618523..28670741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081852.1 → XP_038937780.1  dedicator of cytokinesis protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ANH8
      Conserved Domains (3) summary
      cd08696
      Location:547 → 724
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1633 → 2055
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    2. XM_039081851.1 → XP_038937779.1  dedicator of cytokinesis protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ANH8
      Conserved Domains (3) summary
      cd08696
      Location:547 → 724
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1637 → 2059
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    3. XM_039081850.1 → XP_038937778.1  dedicator of cytokinesis protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANH8
      Conserved Domains (3) summary
      cd08696
      Location:547 → 724
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1668 → 2090
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    4. XM_063265870.1 → XP_063121940.1  dedicator of cytokinesis protein 6 isoform X5

    5. XM_063265869.1 → XP_063121939.1  dedicator of cytokinesis protein 6 isoform X4

    6. XM_039081854.2 → XP_038937782.1  dedicator of cytokinesis protein 6 isoform X6

      UniProtKB/TrEMBL
      A6JNU8
      Conserved Domains (3) summary
      cd08696
      Location:547 → 724
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1629 → 1772
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    7. XM_039081855.2 → XP_038937783.1  dedicator of cytokinesis protein 6 isoform X7

      Conserved Domains (2) summary
      cd08696
      Location:547 → 724
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108997.1: Suppressed sequence

      Description
      NM_001108997.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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