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    Plppr2 phospholipid phosphatase related 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300443, updated on 2-May-2024

    Summary

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    Official Symbol
    Plppr2provided by RGD
    Official Full Name
    phospholipid phosphatase related 2provided by RGD
    Primary source
    RGD:1597171
    See related
    Ensembl:ENSRNOG00000012164 AllianceGenome:RGD:1597171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lppr2; Prg-4
    Summary
    Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human PLPPR2 (phospholipid phosphatase related 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 65.7), Testes (RPKM 11.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plppr2 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28742787..28755555)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20467071..20479474)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22946787..22959554)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159 Neighboring gene SWIM-type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Savaskan NE, et al. Eur J Neurosci, 2004 Jan. PMID 14750979
    2. Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes. Andreev DE, et al. Genome Biol, 2015 May 6. PMID 25943107, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipid phosphate phosphatase-related protein type 2; phospholipid phosphatase-related protein type 2
    Names
    plasticity related protein 4
    NP_001005881.2
    XP_006242690.1
    XP_063121123.1
    XP_063121124.1
    XP_063121125.1
    XP_063121126.1
    XP_063121127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005881.4 → NP_001005881.2  lipid phosphate phosphatase-related protein type 2

      See identical proteins and their annotated locations for NP_001005881.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNW2, F1LR33
      Related
      ENSRNOP00000016790.5, ENSRNOT00000016790.7
      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28742787..28755555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265053.1 → XP_063121123.1  phospholipid phosphatase-related protein type 2 isoform X2

    2. XM_006242628.5 → XP_006242690.1  phospholipid phosphatase-related protein type 2 isoform X1

      Conserved Domains (1) summary
      cd03384
      Location:125 → 281
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    3. XM_063265054.1 → XP_063121124.1  phospholipid phosphatase-related protein type 2 isoform X3

    4. XM_063265056.1 → XP_063121126.1  phospholipid phosphatase-related protein type 2 isoform X5

    5. XM_063265055.1 → XP_063121125.1  phospholipid phosphatase-related protein type 2 isoform X4

    6. XM_063265057.1 → XP_063121127.1  phospholipid phosphatase-related protein type 2 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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