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    Pctp phosphatidylcholine transfer protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29510, updated on 2-May-2024

    Summary

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    Official Symbol
    Pctpprovided by RGD
    Official Full Name
    phosphatidylcholine transfer proteinprovided by RGD
    Primary source
    RGD:3276
    See related
    Ensembl:ENSRNOG00000002425 AllianceGenome:RGD:3276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PC-TP; stARD2
    Summary
    Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phospholipid transport. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in cytosol. Orthologous to human PCTP (phosphatidylcholine transfer protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 243.0), Testes (RPKM 114.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75305999..75351919, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74808887..74856260, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (77491445..77537268, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC134480856 Neighboring gene uncharacterized LOC120095174 Neighboring gene uncharacterized LOC103693415 Neighboring gene transmembrane protein 100 Neighboring gene small integral membrane protein 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and gene structure of rat phosphatidylcholine transfer protein, Pctp. Wu MK, et al. Gene, 1999 Jul 22. PMID 10415339
    2. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Roderick SL, et al. Nat Struct Biol, 2002 Jul. PMID 12055623
    3. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. Kang HW, et al. J Lipid Res, 2009 Nov. PMID 19502644, Free PMC Article
    4. cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene. Geijtenbeek TB, et al. Biochem J, 1996 May 15. PMID 8645232, Free PMC Article
    5. Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice. Wu MK, et al. Am J Physiol Gastrointest Liver Physiol, 2005 Sep. PMID 15845870

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylcholine transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylcholine transfer protein
    Names
    START domain-containing protein 2
    stAR-related lipid transfer protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322798.1 → NP_001309727.1  phosphatidylcholine transfer protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      FN798834, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AL88
      Related
      ENSRNOP00000093865.1, ENSRNOT00000095165.1
      Conserved Domains (1) summary
      cl14643
      Location:1 → 98
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. NM_017225.3 → NP_058921.1  phosphatidylcholine transfer protein isoform 1

      See identical proteins and their annotated locations for NP_058921.1

      Status: VALIDATED

      Source sequence(s)
      FN798833, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P53809, Q9Z2N9
      UniProtKB/TrEMBL
      A6HI08
      Related
      ENSRNOP00000003295.1, ENSRNOT00000003295.5
      Conserved Domains (1) summary
      cd08910
      Location:4 → 210
      START_STARD2-like; Lipid-binding START domain of mammalian STARD2 and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      75305999..75351919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085770.2 → XP_038941698.1  phosphatidylcholine transfer protein isoform X2

      UniProtKB/TrEMBL
      A6HI09
      Conserved Domains (1) summary
      cl14643
      Location:1 → 138
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_008767983.3 → XP_008766205.1  phosphatidylcholine transfer protein isoform X2

      See identical proteins and their annotated locations for XP_008766205.1

      UniProtKB/TrEMBL
      A6HI09
      Conserved Domains (1) summary
      cl14643
      Location:1 → 138
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. XM_006247125.4 → XP_006247187.1  phosphatidylcholine transfer protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP06
      Related
      ENSRNOP00000079674.1
      Conserved Domains (1) summary
      cl14643
      Location:4 → 170
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53809.2 GenPept UniProtKB/Swiss-Prot:P53809

    Gene LinkOut

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