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    Kank2 KN motif and ankyrin repeat domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361376, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Kank2provided by RGD
    Official Full Name
    KN motif and ankyrin repeat domains 2provided by RGD
    Primary source
    RGD:2320289
    See related
    Ensembl:ENSRNOG00000010643 AllianceGenome:RGD:2320289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563532
    Summary
    Predicted to be involved in several processes, including glomerular visceral epithelial cell migration; negative regulation of G1/S transition of mitotic cell cycle; and regulation of signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 355.2), Lung (RPKM 228.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kank2 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28587770..28617212, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20311676..20341107, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22792000..22821459, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin-like 8 Neighboring gene uncharacterized LOC120094090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-κB p65 inhibition. Li L, et al. Int Immunopharmacol, 2020 Sep. PMID 32570033
    2. CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases. Jurewicz E, et al. Neurochem Int, 2020 Sep. PMID 32544715
    3. Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair. Ramot Y, et al. J Med Genet, 2014 Jun. PMID 24671081
    4. Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. Wang D, et al. J Biol Chem, 2012 Apr 13. PMID 22371500, Free PMC Article
    5. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. Zhang Y, et al. EMBO J, 2007 Jun 6. PMID 17476305, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
      Title: CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
    2. Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-kappaB p65 inhibition.
      Title: Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-κB p65 inhibition.
    3. In rats, KANK1, KANK2, and KANK4 all localized to podocytes in glomeruli, and KANK1 partially colocalized with synaptopodin.
      Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney epithelium development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney epithelium development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney epithelium development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vitamin D receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vitamin D receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vitamin D receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in podocyte cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in podocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in podocyte cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270413.1 → NP_001257342.1  KN motif and ankyrin repeat domain-containing protein 2

      See identical proteins and their annotated locations for NP_001257342.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2QNK4, A6JNU5, D4ACC2
      Conserved Domains (6) summary
      cd00204
      Location:650 → 781
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:31 → 59
      KN_motif; KN motif
      pfam12796
      Location:660 → 758
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631 → 676
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:747 → 802
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:728 → 758
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28587770..28617212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242589.5 → XP_006242651.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006242651.1

      UniProtKB/Swiss-Prot
      D3ZD05
      UniProtKB/TrEMBL
      A0A8L2QNK4
      Related
      ENSRNOP00000048736.4
      Conserved Domains (5) summary
      cd00204
      Location:657 → 788
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:735 → 765
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 59
      KN_motif; KN motif
      pfam12796
      Location:624 → 687
      Ank_2; Ankyrin repeats (3 copies)
      cl00478
      Location:438 → 580
      LGT; Prolipoprotein diacylglyceryl transferase

    2. XM_006242590.5 → XP_006242652.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006242652.1

      UniProtKB/Swiss-Prot
      D3ZD05
      UniProtKB/TrEMBL
      A0A8L2QNK4
      Related
      ENSRNOP00000014135.6
      Conserved Domains (5) summary
      cd00204
      Location:657 → 788
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:735 → 765
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 59
      KN_motif; KN motif
      pfam12796
      Location:624 → 687
      Ank_2; Ankyrin repeats (3 copies)
      cl00478
      Location:438 → 580
      LGT; Prolipoprotein diacylglyceryl transferase

    3. XM_063264709.1 → XP_063120779.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3ZD05
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZD05.2 GenPept UniProtKB/Swiss-Prot:D3ZD05

    Gene LinkOut

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