Kcnma1 potassium calcium-activated channel subfamily M alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnma1provided by RGD
Official Full Name: potassium calcium-activated channel subfamily M alpha 1provided by RGD
Primary source: RGD:620715
See related: Ensembl:ENSRNOG00000005985 AllianceGenome:RGD:620715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slo; BKCa; cbv1; slo1; Kcnma; maxiK; KCa1.1; KCNMA1b; KCNMA1c; slo-alpha; BKCA alpha; k(VCA)alpha
Summary: Enables identical protein binding activity; large conductance calcium-activated potassium channel activity; and ligand-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Located in several cellular components, including external side of plasma membrane; neuronal cell body; and presynaptic active zone membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 166.7), Adrenal (RPKM 61.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (351065..1057117)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (302480..1007675)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (344204..1048849)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression.
Title: The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not K(Ca)1.1 channel expression.
TRPC6 interacted with KCa1.1 channels to regulate the proliferation and apoptosis of glioma cells.
Title: TRPC6 interacted with K(Ca)1.1 channels to regulate the proliferation and apoptosis of glioma cells.
Moderate-intensity exercise training reduces vasorelaxation of mesenteric arteries: role of BKCa channels and nitric oxide.
Title: Moderate-intensity exercise training reduces vasorelaxation of mesenteric arteries: role of BKCa channels and nitric oxide.
Estrogen-dependent KCa1.1 modulation is essential for retaining neuroexcitation of female-specific subpopulation of myelinated Ah-type baroreceptor neurons in rats.
Title: Estrogen-dependent KCa1.1 modulation is essential for retaining neuroexcitation of female-specific subpopulation of myelinated Ah-type baroreceptor neurons in rats.
Alteration of sphingosine-1-phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca(2+) -activated K(+) channel (BKCa ) upregulation.
Title: Alteration of sphingosine-1-phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca(2+) -activated K(+) channel (BK(Ca) ) upregulation.
Deletion of BK channels decreased skeletal and cardiac muscle function but increased smooth muscle contraction in rats.
Title: Deletion of BK channels decreased skeletal and cardiac muscle function but increased smooth muscle contraction in rats.
Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
Title: Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
this study shows that long-term, low-dose pretreatment with vitamin C could reduce MCAO-induced brain damage through activation of the BKCa channels, suggesting that the BKCa channel is a molecular target of vitamin C on stroke.
Title: BK(Ca) channel is a molecular target of vitamin C to protect against ischemic brain stroke.
The interactions of fibroblast-like synoviocytes in collagen-induced arthritis are regulated by KCa1.1 and Kv1.3.
Title: KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.
Results show that outward K+ currents, mainly BKCa currents, are significantly upregulated in Muller cells in chronic ocular hypertension rats and these upregulated currents attenuate Muller cells gliosis; and further provide evidence showing that the upregulation of BKCa currents in Muller cells is mediated by the dopamine (DA)/D1 receptor (D1R) system.
Title: Dopamine D1 receptor-mediated upregulation of BK(Ca) currents modifies Müller cell gliosis in a rat chronic ocular hypertension model.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE101789 (e-PCR)
- UniSTS:243714

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:143672

BF405369 (e-PCR)
- UniSTS:247892

D14Mit208 (e-PCR), detects polymorphism
- UniSTS:127321

D15Rat108 (e-PCR), detects polymorphism
- UniSTS:226673

D15Rat135 (e-PCR)
- UniSTS:226695

BF386160 (e-PCR)
- UniSTS:243597

D15Rat73 (e-PCR)
- UniSTS:118416

BE113518 (e-PCR)
- UniSTS:246691

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516539

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516540

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516541

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516543

Kcnma1 (e-PCR), detects polymorphism
- UniSTS:516545

WI-18797 (e-PCR)
- UniSTS:36809

U09383 (e-PCR)
- UniSTS:125659

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	TAS Traceable Author Statement more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables large conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables large conductance calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables large conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables large conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion-gated channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within columnar/cuboidal epithelial cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eye blink reflex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotor rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within micturition	ISO Inferred from Sequence Orthology more info
involved_in micturition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small intestine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of aldosterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to carbon monoxide	IEA Inferred from Electronic Annotation more info
involved_in response to carbon monoxide	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within saliva secretion	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle contraction involved in micturition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle contraction involved in micturition	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle contraction involved in micturition	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-activated potassium channel subunit alpha-1

Names: BK channel; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel, subfamily M subunit alpha-1; maxi K channel; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; slo homolog; slowpoke homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393699.1 → NP_001380628.1 calcium-activated potassium channel subunit alpha-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KKU7

Related

ENSRNOP00000082424.1, ENSRNOT00000109865.1

Conserved Domains (2) summary

PLN03192
Location:217 → 393

PLN03192; Voltage-dependent potassium channel; Provisional

PRK10537
Location:343 → 415

PRK10537; voltage-gated potassium channel protein
NM_001393700.1 → NP_001380629.1 calcium-activated potassium channel subunit alpha-1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KKU6, A6KKU7

Related

ENSRNOP00000061684.3, ENSRNOT00000066928.4

Conserved Domains (3) summary

pfam00520
Location:179 → 396

Ion_trans; Ion transport protein

pfam03493
Location:538 → 633

BK_channel_a; Calcium-activated BK potassium channel alpha subunit

cl21454
Location:446 → 523

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001393701.1 → NP_001380630.1 calcium-activated potassium channel subunit alpha-1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3

UniProtKB/TrEMBL

A0A8I6ABY5

Related

ENSRNOP00000090930.1, ENSRNOT00000096488.1

Conserved Domains (2) summary

PLN03192
Location:217 → 393

PLN03192; Voltage-dependent potassium channel; Provisional

PRK10537
Location:343 → 415

PRK10537; voltage-gated potassium channel protein
NM_031828.2 → NP_114016.2 calcium-activated potassium channel subunit alpha-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

O08626, O55180, O88659, Q62976, Q7TMZ7, Q7TMZ8, Q7TQ55, Q7TQ56, Q7TQ57, Q9WUI3

UniProtKB/TrEMBL

A0A8I6A598

Related

ENSRNOP00000086150.1, ENSRNOT00000105174.1

Conserved Domains (2) summary

PLN03192
Location:217 → 393

PLN03192; Voltage-dependent potassium channel; Provisional

PRK10537
Location:343 → 415

PRK10537; voltage-gated potassium channel protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

351065..1057117

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274728.1 → XP_063130798.1 calcium-activated potassium channel subunit alpha-1 isoform X30
XM_063274726.1 → XP_063130796.1 calcium-activated potassium channel subunit alpha-1 isoform X28
XM_063274727.1 → XP_063130797.1 calcium-activated potassium channel subunit alpha-1 isoform X29
XM_063274699.1 → XP_063130769.1 calcium-activated potassium channel subunit alpha-1 isoform X1
XM_063274700.1 → XP_063130770.1 calcium-activated potassium channel subunit alpha-1 isoform X2
XM_063274706.1 → XP_063130776.1 calcium-activated potassium channel subunit alpha-1 isoform X8
XM_063274707.1 → XP_063130777.1 calcium-activated potassium channel subunit alpha-1 isoform X9
XM_063274702.1 → XP_063130772.1 calcium-activated potassium channel subunit alpha-1 isoform X4
XM_063274703.1 → XP_063130773.1 calcium-activated potassium channel subunit alpha-1 isoform X5
XM_063274704.1 → XP_063130774.1 calcium-activated potassium channel subunit alpha-1 isoform X6
XM_063274705.1 → XP_063130775.1 calcium-activated potassium channel subunit alpha-1 isoform X7
XM_063274709.1 → XP_063130779.1 calcium-activated potassium channel subunit alpha-1 isoform X11
XM_063274710.1 → XP_063130780.1 calcium-activated potassium channel subunit alpha-1 isoform X12
XM_063274701.1 → XP_063130771.1 calcium-activated potassium channel subunit alpha-1 isoform X3
XM_063274715.1 → XP_063130785.1 calcium-activated potassium channel subunit alpha-1 isoform X17

UniProtKB/TrEMBL

F1LNC7
XM_063274708.1 → XP_063130778.1 calcium-activated potassium channel subunit alpha-1 isoform X10
XM_063274714.1 → XP_063130784.1 calcium-activated potassium channel subunit alpha-1 isoform X16
XM_063274711.1 → XP_063130781.1 calcium-activated potassium channel subunit alpha-1 isoform X13
XM_063274729.1 → XP_063130799.1 calcium-activated potassium channel subunit alpha-1 isoform X31
XM_063274717.1 → XP_063130787.1 calcium-activated potassium channel subunit alpha-1 isoform X19
XM_063274720.1 → XP_063130790.1 calcium-activated potassium channel subunit alpha-1 isoform X22
XM_063274716.1 → XP_063130786.1 calcium-activated potassium channel subunit alpha-1 isoform X18

UniProtKB/TrEMBL

A6KKU8
XM_063274723.1 → XP_063130793.1 calcium-activated potassium channel subunit alpha-1 isoform X25
XM_063274712.1 → XP_063130782.1 calcium-activated potassium channel subunit alpha-1 isoform X14
XM_063274713.1 → XP_063130783.1 calcium-activated potassium channel subunit alpha-1 isoform X15
XM_063274722.1 → XP_063130792.1 calcium-activated potassium channel subunit alpha-1 isoform X24
XM_063274724.1 → XP_063130794.1 calcium-activated potassium channel subunit alpha-1 isoform X26
XM_063274730.1 → XP_063130800.1 calcium-activated potassium channel subunit alpha-1 isoform X32
XM_063274721.1 → XP_063130791.1 calcium-activated potassium channel subunit alpha-1 isoform X23

UniProtKB/TrEMBL

A6KKU5
XM_063274725.1 → XP_063130795.1 calcium-activated potassium channel subunit alpha-1 isoform X27
XM_063274718.1 → XP_063130788.1 calcium-activated potassium channel subunit alpha-1 isoform X20
XM_063274719.1 → XP_063130789.1 calcium-activated potassium channel subunit alpha-1 isoform X21