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    Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361574, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Snrnp70provided by RGD
    Official Full Name
    small nuclear ribonucleoprotein U1 subunit 70provided by RGD
    Primary source
    RGD:1307120
    See related
    Ensembl:ENSRNOG00000020763 AllianceGenome:RGD:1307120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Snrp70
    Summary
    Enables U1 snRNP binding activity. Involved in cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and cellular response to tumor necrosis factor. Located in cytoplasm and nucleus. Part of U1 snRNP. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 344.1), Adrenal (RPKM 324.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrnp70 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104992518..105012851, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95856038..95876434, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101367470..101388153, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 3 Neighboring gene uncharacterized LOC120097162 Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene neurotrophin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Monneaux F, et al. Eur J Immunol, 2000 Aug. PMID 10940910
    2. Dual posttranscriptional targets of retinoic acid-induced gene expression. Manji SS, et al. J Cell Biochem, 1999 Mar 1. PMID 10022522
    3. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study. Katsumata Y, et al. Mod Rheumatol, 2013 Jan. PMID 22454191
    4. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Query CC, et al. Cell, 1989 Apr 7. PMID 2467746
    5. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Bai B, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24023061, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U1 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein 70 kDa
    Names
    U1 small nuclear ribonucleoprotein polypeptide A
    small nuclear ribonucleoprotein 70 (U1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399641.1 → NP_001386570.1  U1 small nuclear ribonucleoprotein 70 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      B2RZ74, F7FIU1
      Related
      ENSRNOP00000028176.3, ENSRNOT00000028176.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104992518..105012851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229102.5 → XP_006229164.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X1

      See identical proteins and their annotated locations for XP_006229164.1

      UniProtKB/TrEMBL
      A0A8I6G5W4, B2RZ74, F7FIU1
      Conserved Domains (3) summary
      COG0724
      Location:26 → 182
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12236
      Location:102 → 187
      RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
      pfam12220
      Location:2 → 93
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108483.1: Suppressed sequence

      Description
      NM_001108483.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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