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    Epb41l5 erythrocyte membrane protein band 4.1 like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304733, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Epb41l5provided by RGD
    Official Full Name
    erythrocyte membrane protein band 4.1 like 5provided by RGD
    Primary source
    RGD:1311366
    See related
    Ensembl:ENSRNOG00000002538 AllianceGenome:RGD:1311366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb4.1l5
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in actomyosin structure organization and epithelial to mesenchymal transition. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Predicted to be located in several cellular components, including focal adhesion; nucleoplasm; and ruffle membrane. Predicted to be active in cytoskeleton. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 255.7), Lung (RPKM 220.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epb41l5 in Genome Data Viewer
    Location:
    13q11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (33221705..33321400, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (30670792..30770213, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (35622472..35673449, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 185B Neighboring gene protein tyrosine phosphatase, non-receptor type 4 Neighboring gene uncharacterized LOC134481550 Neighboring gene ankyrin repeat domain 49, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epithelial cell shape is regulated by Lulu proteins via myosin-II. Nakajima H, et al. J Cell Sci, 2010 Feb 15. PMID 20103536
    2. Left-right patterning in the mouse requires Epb4.1l5-dependent morphogenesis of the node and midline. Lee JD, et al. Dev Biol, 2010 Oct 15. PMID 20678497, Free PMC Article
    3. The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Lee JD, et al. Development, 2007 Jun. PMID 17507402
    4. EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. Hirano M, et al. J Cell Biol, 2008 Sep 22. PMID 18794329, Free PMC Article
    5. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109531

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apical constriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axial mesoderm morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ectoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within left/right axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mesoderm migration involved in gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural plate morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within paraxial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somite rostral/caudal axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substrate-dependent cell migration, cell attachment to substrate ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within unidimensional cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 5
    Names
    erythrocyte protein band 4.1-like 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012023.1 → NP_001012023.1  band 4.1-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001012023.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090012
      UniProtKB/TrEMBL
      D3ZK45
      Related
      ENSRNOP00000045431.4, ENSRNOT00000042862.6
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl28922
      Location:41 → 126
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001401160.1 → NP_001388089.1  band 4.1-like protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      Related
      ENSRNOP00000089466.1, ENSRNOT00000111356.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      33221705..33321400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090680.2 → XP_038946608.1  band 4.1-like protein 5 isoform X2

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    2. XM_039090673.2 → XP_038946601.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    3. XM_039090679.2 → XP_038946607.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    4. XM_039090678.2 → XP_038946606.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    5. XM_039090675.2 → XP_038946603.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    6. XM_063272230.1 → XP_063128300.1  band 4.1-like protein 5 isoform X2

    7. XM_039090671.2 → XP_038946599.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    8. XM_039090676.2 → XP_038946604.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    9. XM_039090677.2 → XP_038946605.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    10. XM_039090674.2 → XP_038946602.1  band 4.1-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q5FVG2
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl40461
      Location:477 → 510
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    11. XM_063272234.1 → XP_063128304.1  band 4.1-like protein 5 isoform X3

    12. XM_063272233.1 → XP_063128303.1  band 4.1-like protein 5 isoform X3

    13. XM_063272232.1 → XP_063128302.1  band 4.1-like protein 5 isoform X3

    14. XM_063272231.1 → XP_063128301.1  band 4.1-like protein 5 isoform X3

    15. XM_039090681.2 → XP_038946609.1  band 4.1-like protein 5 isoform X3

      UniProtKB/TrEMBL
      D3ZK45
      Conserved Domains (4) summary
      smart00295
      Location:44 → 235
      B41; Band 4.1 homologues
      cd13186
      Location:231 → 324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam08736
      Location:337 → 378
      FA; FERM adjacent (FA)
      cl28922
      Location:41 → 126
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    16. XM_063272235.1 → XP_063128305.1  band 4.1-like protein 5 isoform X3

    17. XM_063272236.1 → XP_063128306.1  band 4.1-like protein 5 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVG2.2 GenPept UniProtKB/Swiss-Prot:Q5FVG2

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