ptprn2 protein tyrosine phosphatase receptor type N2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptprn2provided by ZNC
Official Full Name: protein tyrosine phosphatase receptor type N2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3758
See related: Ensembl:ENSDARG00000035970 AllianceGenome:ZFIN:ZDB-GENE-030131-3758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IA-2[b]; fc52a08; im:7153814; wu:fc52a08
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in secretory granule; synapse; and transport vesicle membrane. Predicted to be integral component of membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (40228349..40499382)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (39957345..40228365)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc52a08 (e-PCR)
- UniSTS:189305

G47113 (e-PCR)
- UniSTS:107902

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase N2

Names: protein tyrosine phosphatase, receptor type, N polypeptide 2

NP_001122139.1

EC 3.1.3.48

XP_021333079.1

EC 3.1.3.48

XP_021333080.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128667.1 → NP_001122139.1 receptor-type tyrosine-protein phosphatase N2 precursor

Status: VALIDATED

Source sequence(s)

BX005327, BX248235

UniProtKB/TrEMBL

A0A8N7UZ33, A3KPJ4

Related

ENSDARP00000052221.8, ENSDART00000052222.9

Conserved Domains (4) summary

smart00194
Location:757 → 1016

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:785 → 1016

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam11548
Location:518 → 602

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:50 → 105

RESP18; RESP18 domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

40228349..40499382

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477405.1 → XP_021333080.1 receptor-type tyrosine-protein phosphatase N2 isoform X2

UniProtKB/TrEMBL

A0A8M9QGN0

Conserved Domains (2) summary

smart00194
Location:719 → 978

PTPc; Protein tyrosine phosphatase, catalytic domain

pfam11548
Location:478 → 564

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
XM_021477404.1 → XP_021333079.1 receptor-type tyrosine-protein phosphatase N2 isoform X1

UniProtKB/TrEMBL

A0A8M9Q7I8

Conserved Domains (3) summary

smart00194
Location:741 → 1000

PTPc; Protein tyrosine phosphatase, catalytic domain

pfam11548
Location:500 → 586

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:34 → 89

RESP18; RESP18 domain