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    Rassf5 Ras association domain family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54355, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rassf5provided by RGD
    Official Full Name
    Ras association domain family member 5provided by RGD
    Primary source
    RGD:621694
    See related
    Ensembl:ENSRNOG00000005342 AllianceGenome:RGD:621694
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Maxp1; Nore1
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of cell population proliferation; positive regulation of protein ubiquitination; and regulation of protein localization to nucleus. Predicted to be located in cytoplasm and microtubule. Predicted to be active in nucleus. Orthologous to human RASSF5 (Ras association domain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 158.5), Thymus (RPKM 152.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rassf5 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45189768..45255277, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42637513..42703024, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47956754..48022333, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481556 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene uncharacterized LOC134481557 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon Neighboring gene uncharacterized LOC120096246 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Shinmura K, et al. Lung Cancer, 2011 Jan. PMID 20434789
    2. Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase. Nakamura T, et al. Genes Cells, 2013 Nov. PMID 24165023
    3. Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1. Katagiri K, et al. Immunity, 2011 Jan 28. PMID 21194982
    4. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. Vos MD, et al. J Biol Chem, 2003 Jun 13. PMID 12676952
    5. Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats. Gezginci-Oktayoglu S, et al. Apoptosis, 2012 Jan. PMID 21938476

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase.
      Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
    2. Apoptotic Ras effector molecules RASSF1 and NORE1 play important role in NGF reduction and TNF-alpha-related pancreatic beta cell apoptosis in hyperglycemic rats.
      Title: Ras signaling in NGF reduction and TNF-α-related pancreatic β cell apoptosis in hyperglycemic rats.
    3. Nore1 is a member of a family of Ras effector/tumor suppressors that includes RASSF1
      Title: The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 5
    Names
    Ras association (RalGDS/AF-6) domain family member 5
    new ras effector 1
    novel ras effector 1
    protein interacting with guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019365.4 → NP_062238.1  ras association domain-containing protein 5

      See identical proteins and their annotated locations for NP_062238.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      O35141
      UniProtKB/TrEMBL
      A6IC16
      Related
      ENSRNOP00000008055.3, ENSRNOT00000008055.6
      Conserved Domains (3) summary
      cd01778
      Location:267 → 360
      RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
      pfam16517
      Location:366 → 405
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00040
      Location:118 → 166
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45189768..45255277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769494.4 → XP_008767716.1  ras association domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY99
      Related
      ENSRNOP00000070574.1
      Conserved Domains (2) summary
      cd01778
      Location:119 → 212
      RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
      pfam16517
      Location:218 → 257
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35141.1 GenPept UniProtKB/Swiss-Prot:O35141

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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