BCL10 B-cell CLL/lymphoma 10 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: BCL10provided by CGNC
Official Full Name: B-cell CLL/lymphoma 10provided by CGNC
Primary source: CGNC:6578
See related: Ensembl:ENSGALG00010020681
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (16014036..16021904)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (16023159..16031036)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clustal W alignment of orthologous regions of Bcl10 from various mammals (mouse, human, and rat), birds (chicken), and fish (fugu) from amino acids 79-104 of the mouse sequence was done, to identify conserved residues and structural modeling of the Bcl
Title: Multiple protein domains mediate interaction between Bcl10 and MALT1.
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
Title: IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info	PubMed
enables kinase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase B binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of CBM complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: B-cell lymphoma/leukemia 10

Names: B-cell lymophoma 10 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201487.3 → NP_001188416.2 B-cell lymphoma/leukemia 10

Status: VALIDATED

Source sequence(s)

JAENSK010000239

UniProtKB/TrEMBL

E7EC82, R4GI14

Related

ENSGALP00010029508.1, ENSGALT00010049957.1

Conserved Domains (1) summary

cd08810
Location:24 → 107

CARD_BCL10; Caspase activation and recruitment domain of B-cell lymphoma 10