zc3h12ab zinc finger CCCH-type containing 12Ab [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zc3h12abprovided by ZNC
Official Full Name: zinc finger CCCH-type containing 12Abprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081031-82
See related: Ensembl:ENSDARG00000101034 AllianceGenome:ZFIN:ZDB-GENE-081031-82
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-206d17.12
Summary: Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization; RNA phosphodiester bond hydrolysis, endonucleolytic; and nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (3803437..3821678, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (3862539..3880780, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein LOC563108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171029.1 → NP_001164500.1 uncharacterized protein LOC563108

Status: PREDICTED

Source sequence(s)

CT030005

UniProtKB/TrEMBL

A0A8M1NUF4, B8JJU9

Related

ENSDARP00000136372.1, ENSDART00000169639.2

Conserved Domains (2) summary

pfam00642
Location:326 → 349

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam11977
Location:162 → 317

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain