STR2 cystathionine gamma-synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: STR2
Gene description: cystathionine gamma-synthase
Primary source: FungiDB:YJR130C
Locus tag: YJR130C
See related: SGD:S000003891; AllianceGenome:SGD:S000003891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cystathionine gamma-synthase activity. Involved in transsulfuration. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See STR2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (665218..667137, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cystathionine gamma-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-synthase activity	IEA Inferred from Electronic Annotation more info
enables cystathionine gamma-synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cystathionine gamma-synthase activity (acts on O-phosphohomoserine)	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sulfur compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info
involved_in transsulfuration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cystathionine gamma-synthase

NP_012664.1

EC 2.5.1.48

Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

665218..667137 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181788.1 → NP_012664.1 TPA: cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012664.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWU8, P47164

UniProtKB/TrEMBL

A6ZQ85, B3LQL2, C7GM83, C8ZBS8, N1P8X1

Conserved Domains (1) summary

COG0626
Location:203 → 637

MetC; Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]