iqgap1 IQ motif containing GTPase activating protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: iqgap1provided by ZNC
Official Full Name: IQ motif containing GTPase activating protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050809-24
See related: Ensembl:ENSDARG00000078888 AllianceGenome:ZFIN:ZDB-GENE-050809-24
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7152854; im:7156663
Summary: Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within regulation of GTPase activity and signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; ectoderm; gut; perichondrium; and pharyngeal arch. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (50644424..50764507, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (50371642..50489211, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc86g01.x1 (e-PCR)
- UniSTS:194690

G45157 (e-PCR)
- UniSTS:105959

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras GTPase-activating-like protein IQGAP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308966.1 → NP_001295895.1 ras GTPase-activating-like protein IQGAP1

See identical proteins and their annotated locations for NP_001295895.1

Status: PROVISIONAL

Source sequence(s)

KP862587

UniProtKB/TrEMBL

A0A0F7C9F3

Related

ENSDARP00000098704.2, ENSDART00000110283.5

Conserved Domains (6) summary

smart00015
Location:774 → 794

IQ; Calmodulin-binding motif

smart00323
Location:991 → 1343

RasGAP; GTPase-activator protein for Ras-like GTPases

cd00014
Location:43 → 157

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00201
Location:682 → 711

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam03836
Location:1453 → 1578

RasGAP_C; RasGAP C-terminus

cl02569
Location:1002 → 1381

RasGAP; Ras GTPase Activating Domain