stat1b signal transducer and activator of transcription 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stat1bprovided by ZNC
Official Full Name: signal transducer and activator of transcription 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-23
See related: Ensembl:ENSDARG00000076182 Ensembl:ENSDARG00000095475 AllianceGenome:ZFIN:ZDB-GENE-030616-23
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: STAT; STAT1; zgc:55503; wu:fi49f02; si:dz73o4.3; si:dz87i4.1; si:by51f19.2; si:by134g18.3; si:dz199m19.1; si:dz199m19.2; si:xx-51f19.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in cytoplasm and nucleus. Is expressed in cardiovascular system; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 9

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (41218898..41268830)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (41417122..41445410)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ISGF3 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: signal transducer and activator of transcription 1b

Names: signal transducer and activator of transcription 1, 91kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200091.2 → NP_956385.2 signal transducer and activator of transcription 1b

See identical proteins and their annotated locations for NP_956385.2

Status: VALIDATED

Source sequence(s)

BX649377

UniProtKB/TrEMBL

A0A8N7V0P4, B0S789

Related

ENSDARP00000000280.9, ENSDART00000000280.11

Conserved Domains (4) summary

cd16845
Location:320 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl28921
Location:138 → 316

STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain

pfam02865
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

cl15255
Location:559 → 697

SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

41218898..41268830

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478620.1 → XP_021334295.1 signal transducer and activator of transcription 1b isoform X4

UniProtKB/TrEMBL

A0A8M9QJJ2

Conserved Domains (4) summary

pfam01017
Location:138 → 316

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:320 → 567

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

cl15255
Location:558 → 622

SH2; Src homology 2 (SH2) domain
XM_021478621.1 → XP_021334296.1 signal transducer and activator of transcription 1b isoform X5

UniProtKB/TrEMBL

A0A8M9QF99

Conserved Domains (4) summary

pfam01017
Location:138 → 316

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:320 → 567

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

cl15255
Location:558 → 624

SH2; Src homology 2 (SH2) domain
XM_021478622.1 → XP_021334297.1 signal transducer and activator of transcription 1b isoform X6

UniProtKB/TrEMBL

A0A8M9PRY3

Conserved Domains (3) summary

pfam01017
Location:138 → 316

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:320 → 567

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 119

STAT_int; STAT protein, protein interaction domain
XM_021478619.1 → XP_021334294.1 signal transducer and activator of transcription 1b isoform X3

UniProtKB/TrEMBL

A0A8M9QAL7

Conserved Domains (4) summary

pfam01017
Location:138 → 316

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:320 → 567

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

cl15255
Location:558 → 680

SH2; Src homology 2 (SH2) domain
XM_009304879.3 → XP_009303154.1 signal transducer and activator of transcription 1b isoform X2

UniProtKB/TrEMBL

A0A8M3B5U5

Conserved Domains (4) summary

pfam01017
Location:121 → 299

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:303 → 551

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:31 → 102

STAT_int; STAT protein, protein interaction domain

cl15255
Location:542 → 680

SH2; Src homology 2 (SH2) domain
XM_005167878.4 → XP_005167935.1 signal transducer and activator of transcription 1b isoform X1

See identical proteins and their annotated locations for XP_005167935.1

UniProtKB/TrEMBL

A0A8N7V0P4, B0S789

Related

ENSDARP00000115509.1, ENSDART00000145674.3

Conserved Domains (4) summary

cd16845
Location:320 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl28921
Location:138 → 316

STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain

pfam02865
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

cl15255
Location:559 → 697

SH2; Src homology 2 (SH2) domain
XM_021478623.1 → XP_021334298.1 signal transducer and activator of transcription 1b isoform X7

UniProtKB/TrEMBL

A0A8M9Q4I2

Related

ENSDART00000136821.2

Conserved Domains (3) summary

pfam01017
Location:1 → 69

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:73 → 322

STAT_bind; STAT protein, DNA binding domain

cl15255
Location:313 → 435

SH2; Src homology 2 (SH2) domain