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    cwc22 CWC22 spliceosome associated protein homolog [ Danio rerio (zebrafish) ]

    Gene ID: 566033, updated on 27-Mar-2024

    Summary

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    Official Symbol
    cwc22provided by ZNC
    Official Full Name
    CWC22 spliceosome associated protein homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-452
    See related
    Ensembl:ENSDARG00000014008 AllianceGenome:ZFIN:ZDB-GENE-060929-452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb13g08; fi16b02; wu:fb13g08; wu:fi16b02; zgc:153452
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See cwc22 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (43552515..43644261, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (43750721..43864810, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene SEC14 and spectrin domains 1 Neighboring gene zinc finger protein 385B Neighboring gene ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) Neighboring gene integrin alpha 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CERKL knockdown causes retinal degeneration in zebrafish. Riera M, et al. PLoS One, 2013. PMID 23671706, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153452

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor CWC22 homolog
    Names
    nucampholin homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077569.2 → NP_001071037.2  pre-mRNA-splicing factor CWC22 homolog

      Status: VALIDATED

      Source sequence(s)
      BX470219, EH544241
      UniProtKB/Swiss-Prot
      Q08C72
      UniProtKB/TrEMBL
      A0A8N7UYD3, B0S6B1
      Related
      ENSDARP00000013971.9, ENSDART00000023684.10
      Conserved Domains (2) summary
      smart00543
      Location:258 → 439
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      cl02653
      Location:549 → 655
      MA3; MA3 domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      43552515..43644261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08C72.1 GenPept UniProtKB/Swiss-Prot:Q08C72

    Gene LinkOut

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