mkrn4 makorin, ring finger protein, 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mkrn4provided by ZNC
Official Full Name: makorin, ring finger protein, 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5954
See related: Ensembl:ENSDARG00000028295 AllianceGenome:ZFIN:ZDB-GENE-030131-5954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi27c05; wu:fi27c05; si:ch73-237c6.4
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in several structures, including eye; gill; gonad; integument; and liver. Orthologous to human MKRN6P (makorin ring finger protein 6, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (23725957..23731213)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (23704718..23709974)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc59g04 (e-PCR)
- UniSTS:189450

fi27c05.x1 (e-PCR)
- UniSTS:204525

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: makorin, ring finger protein, 4

NP_001121808.1

EC 2.3.2.27

XP_005167100.1

EC 2.3.2.27

XP_021333941.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128336.1 → NP_001121808.1 makorin, ring finger protein, 4

Status: PROVISIONAL

Source sequence(s)

CU302443

UniProtKB/TrEMBL

A0A8M1NJW8, A9C4A6

Related

ENSDARP00000095121.4, ENSDART00000104346.6

Conserved Domains (2) summary

smart00356
Location:48 → 68

ZnF_C3H1; zinc finger

cd00162
Location:234 → 288

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

23725957..23731213

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167043.4 → XP_005167100.1 makorin, ring finger protein, 4 isoform X1

UniProtKB/TrEMBL

A0A8M2BED9

Conserved Domains (2) summary

smart00356
Location:53 → 73

ZnF_C3H1; zinc finger

cd00162
Location:239 → 293

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_021478266.1 → XP_021333941.1 makorin, ring finger protein, 4 isoform X2

UniProtKB/TrEMBL

A0A8M9QDS1

Conserved Domains (1) summary

cd16732
Location:118 → 178

RING-HC_MKRN4; RING finger, HC subclass, found in makorin-4 (MKRN4) and similar proteins