col5a2a collagen, type V, alpha 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: col5a2aprovided by ZNC
Official Full Name: collagen, type V, alpha 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-13
See related: Ensembl:ENSDARG00000031678 AllianceGenome:ZFIN:ZDB-GENE-030616-13
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: COL5A2; col5a2l; im:7038599; wu:fa13f03; wu:fa98d01; wu:fj05e03; si:dz167c3.3; si:by143e18.1; si:ch211-198b21.5
Summary: Predicted to be an extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be part of collagen type V trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including epidermis; median fin fold; paraxial mesoderm; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome classic type 2. Orthologous to human COL5A2 (collagen type V alpha 2 chain). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 54

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (42652073..42696404, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (42850286..42894617, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fa13f03.s1 (e-PCR)
- UniSTS:202364

fj05e03.x1 (e-PCR)
- UniSTS:198395

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of collagen type V trimer	IBA Inferred from Biological aspect of Ancestor more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: collagen, type V, alpha 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145782.1 → NP_001139254.1 collagen, type V, alpha 2a precursor

Status: PROVISIONAL

Source sequence(s)

BX640465

UniProtKB/TrEMBL

A0A8M1NTE7

Related

ENSDARP00000122378.1, ENSDART00000144744.2

Conserved Domains (3) summary

pfam01391
Location:690 → 747

Collagen; Collagen triple helix repeat (20 copies)

pfam00093
Location:36 → 91

VWC; von Willebrand factor type C domain

pfam01410
Location:1260 → 1490

COLFI; Fibrillar collagen C-terminal domain