psmb12 proteasome 20S subunit beta 12 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmb12provided by ZNC
Official Full Name: proteasome 20S subunit beta 12provided by ZNC
Primary source: ZFIN:ZDB-GENE-001208-1
See related: Ensembl:ENSDARG00000031885 AllianceGenome:ZFIN:ZDB-GENE-001208-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: beta1t; psmb11; prosome; macropain; zgc:92422
Summary: Predicted to enable threonine-type endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to act upstream of or within proteolysis involved in cellular protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to human PSMB9 (proteasome 20S subunit beta 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (7115238..7119451)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (7196313..7200526)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasome 20S subunit beta 12

Names: proteasome (prosome, macropain) subunit, beta type, 11; proteasome (prosome, macropain) subunit, beta type, 12; proteasome subunit beta 12

NP_571751.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131676.2 → NP_571751.1 proteasome 20S subunit beta 12

See identical proteins and their annotated locations for NP_571751.1

Status: PROVISIONAL

Source sequence(s)

AF155576

UniProtKB/TrEMBL

B2GR91, Q9PUS6

Related

ENSDARP00000001845.7, ENSDART00000001359.8

Conserved Domains (2) summary

TIGR03690
Location:16 → 211

20S_bact_beta; proteasome, beta subunit, bacterial type

cd03762
Location:17 → 205

proteasome_beta_type_6; proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...