tfpia tissue factor pathway inhibitor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfpiaprovided by ZNC
Official Full Name: tissue factor pathway inhibitor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030711-1
See related: Ensembl:ENSDARG00000034718 AllianceGenome:ZFIN:ZDB-GENE-030711-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TFPI; tfpib; wu:fb92g01; zgc:152844; zgc:158592; si:dz44f8.1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within hemostasis and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin skeleton. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (42420636..42484444, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (42618849..42682657, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish.
Title: Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish.
Knockdown of adtrp1 reduced the expression of tfpi, and hematopoietic defects in adtrp1 morphants were rescued by tfpi overexpression. These data suggest that the regulation of tfpi expression is one potential mechanism by which adtrp1 regulates primitive myelopoiesis and definitive hematopoiesis.
Title: Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.

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General gene information

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Markers

fb92g01.x1 (e-PCR)
- UniSTS:191762

fb92g01.x1 (e-PCR)
- UniSTS:191763

fk30g07.y1 (e-PCR)
- UniSTS:200785

fj04f02.x1 (e-PCR)
- UniSTS:198364

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tissue factor pathway inhibitor a

Names: coagulation inhibitor; lipoprotein-associated; tissue factor pathway inhibitor b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309803.1 → NP_001296732.1 tissue factor pathway inhibitor a isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BX470245, CT943665

UniProtKB/TrEMBL

A0A8M1P282, B0S6C1

Related

ENSDARP00000047652.6, ENSDART00000047653.8

Conserved Domains (2) summary

cd00109
Location:99 → 151

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:42 → 92

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
NM_182872.2 → NP_878292.2 tissue factor pathway inhibitor a isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

BX470245, CT943665

UniProtKB/TrEMBL

A0A8M1PAQ1, E7EXD1

Related

ENSDARP00000048319.7, ENSDART00000048320.7

Conserved Domains (2) summary

cd00109
Location:98 → 150

KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

pfam00014
Location:41 → 91

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain