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    Mxra8 matrix remodeling associated 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313770, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Mxra8provided by RGD
    Official Full Name
    matrix remodeling associated 8provided by RGD
    Primary source
    RGD:1359356
    See related
    Ensembl:ENSRNOG00000019244 AllianceGenome:RGD:1359356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    1200013a08rik
    Summary
    Predicted to be involved in cell adhesion. Predicted to act upstream of or within establishment of glial blood-brain barrier. Predicted to be located in cell surface. Orthologous to human MXRA8 (matrix remodeling associated 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 431.2), Uterus (RPKM 203.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mxra8 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171731153..171735879)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166448919..166453645)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173288200..173292926)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487050 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3 Neighboring gene ceramide-1-phosphate transfer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet. Yonezawa T, et al. Glia, 2003 Dec. PMID 14603461
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95024

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of glial blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of glial blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    matrix remodeling-associated protein 8
    Names
    limitrin
    matrix-remodeling-associated protein 8
    matrix-remodelling associated 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395588.1 → NP_001382517.1  matrix remodeling-associated protein 8 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2KB26, A6IUT4
      Related
      ENSRNOP00000075625.2, ENSRNOT00000091205.2
      Conserved Domains (2) summary
      pfam07686
      Location:171 → 291
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:220 → 226
      Ig; Ig strand C' [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171731153..171735879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239575.1 → XP_006239637.1  matrix remodeling-associated protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB26
      Conserved Domains (2) summary
      smart00410
      Location:99 → 133
      IG_like; Immunoglobulin like
      pfam07686
      Location:168 → 288
      V-set; Immunoglobulin V-set domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007002.1: Suppressed sequence

      Description
      NM_001007002.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI43.1 GenPept UniProtKB/Swiss-Prot:Q5XI43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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