U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrrc24 leucine rich repeat containing 24 [ Mus musculus (house mouse) ]

    Gene ID: 378937, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrrc24provided by MGI
    Official Full Name
    leucine rich repeat containing 24provided by MGI
    Primary source
    MGI:MGI:3605040
    See related
    Ensembl:ENSMUSG00000033707 AllianceGenome:MGI:3605040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430402H13Rik
    Summary
    Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in central nervous system; dorsal root ganglion; and liver. Orthologous to human LRRC24 (leucine rich repeat containing 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 13.7), cerebellum adult (RPKM 13.2) and 24 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lrrc24 in Genome Data Viewer
    Location:
    15 D3; 15 36.28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76599476..76606373, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76715276..76722173, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7385 Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ protein-like 4 Neighboring gene RIKEN cDNA C030006K11 gene Neighboring gene leucine rich repeat containing 14 Neighboring gene Rho GTPase activating protein 39 Neighboring gene STARR-positive B cell enhancer mm9_chr15:76600695-76600996 Neighboring gene predicted gene, 17271 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter. Uwanogho DA, et al. Gene, 2010 Jan 1. PMID 19720120
    2. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
    3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
    4. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine-rich repeat-containing protein 24

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198119.2 → NP_932787.1  leucine-rich repeat-containing protein 24 precursor

      See identical proteins and their annotated locations for NP_932787.1

      Status: PROVISIONAL

      Source sequence(s)
      AK078176
      Consensus CDS
      CCDS27590.1
      UniProtKB/Swiss-Prot
      Q14AD4, Q8BHA1
      Related
      ENSMUSP00000061906.5, ENSMUST00000049956.5
      Conserved Domains (7) summary
      smart00082
      Location:212 → 265
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:274 → 370
      IG_like; Immunoglobulin like
      cd00116
      Location:60 → 166
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:61 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:131 → 171
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:84 → 142
      LRR_8; Leucine rich repeat
      cl11960
      Location:267 → 361
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76599476..76606373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHA1.1 GenPept UniProtKB/Swiss-Prot:Q8BHA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous