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    ZBTB32 zinc finger and BTB domain containing 32 [ Homo sapiens (human) ]

    Gene ID: 27033, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZBTB32provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 32provided by HGNC
    Primary source
    HGNC:HGNC:16763
    See related
    Ensembl:ENSG00000011590 MIM:605859; AllianceGenome:HGNC:16763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Rog; FAXF; FAZF; TZFP; mynn; ZNF538
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 13.5), lymph node (RPKM 1.5) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB32 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35704558..35717038)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38249885..38262352)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36195460..36207940)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene UPK1A antisense RNA 1 Neighboring gene uroplakin 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36174493-36174994 Neighboring gene thymidylate synthetase pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10532 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:36207458-36208017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36209137-36209694 Neighboring gene lysine methyltransferase 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36230671-36231301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14497 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36234871-36235031 Neighboring gene IGF like family receptor 1 Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation. Ikeda R, et al. J Cell Biochem, 2007 May 1. PMID 17171645
    2. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. Lin W, et al. Biochem Biophys Res Commun, 1999 Nov 2. PMID 10544010
    3. ZBTB32 Restricts the Duration of Memory B Cell Recall Responses. Jash A, et al. J Immunol, 2016 Aug 15. PMID 27357154, Free PMC Article
    4. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. Stogios PJ, et al. J Mol Biol, 2010 Jul 30. PMID 20493880
    5. The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. Dai MS, et al. J Biol Chem, 2002 Jul 19. PMID 11986317

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZBTB32 is a novel negative regulator of antibody recall responses.
      Title: ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.
    2. confirmed that the promyelocytic leukemia zinc finger (PLZF) BTB dimer is strand exchanged in solution, while the FAZF BTB dimer is not
      Title: Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.
    3. Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
      Title: Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor.
    4. TZFP is identified as a novel BMP2-induced transcription factor during osteoblastic differentiation.
      Title: Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation.
    5. results suggest an essential role for FAZF during the proliferative stages of primitive hematopoietic progenitors, possibly acting in concert with (a subset of) the Fanconi anemia proteins
      Title: The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific.
    6. can interact with GATA-2 and can modify GATA-2 transactivation capacity
      Title: Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 32
    Names
    FANCC-interacting protein
    fanconi anemia zinc finger protein
    myoneurin
    repressor of GATA
    testis zinc finger protein
    zinc finger protein 538

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316902.2 → NP_001303831.1  zinc finger and BTB domain-containing protein 32 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF130255, HY027719, HY039545
      UniProtKB/Swiss-Prot
      Q9Y2Y4
      Conserved Domains (2) summary
      sd00017
      Location:98 → 118
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:111 → 132
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001316903.2 → NP_001303832.1  zinc finger and BTB domain-containing protein 32 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AF130255, BX095236, HY027719
      UniProtKB/Swiss-Prot
      Q9Y2Y4
      Conserved Domains (2) summary
      COG5048
      Location:41 → 91
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:43 → 63
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_014383.3 → NP_055198.1  zinc finger and BTB domain-containing protein 32 isoform 1

      See identical proteins and their annotated locations for NP_055198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF130255, HY027719
      Consensus CDS
      CCDS12471.1
      UniProtKB/Swiss-Prot
      Q8WVP2, Q9Y2Y4
      Related
      ENSP00000376035.1, ENST00000392197.7
      Conserved Domains (3) summary
      COG5048
      Location:373 → 423
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02518
      Location:23 → 109
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35704558..35717038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026591.2 → XP_016882080.1  zinc finger and BTB domain-containing protein 32 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38249885..38262352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320532.1 → XP_054176507.1  zinc finger and BTB domain-containing protein 32 isoform X3

      UniProtKB/Swiss-Prot
      Q8WVP2, Q9Y2Y4

    2. XM_054320531.1 → XP_054176506.1  zinc finger and BTB domain-containing protein 32 isoform X2

    3. XM_054320535.1 → XP_054176510.1  zinc finger and BTB domain-containing protein 32 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DGF1

    4. XM_054320536.1 → XP_054176511.1  zinc finger and BTB domain-containing protein 32 isoform X1

    5. XM_054320533.1 → XP_054176508.1  zinc finger and BTB domain-containing protein 32 isoform X4

    6. XM_054320534.1 → XP_054176509.1  zinc finger and BTB domain-containing protein 32 isoform X5

    7. XM_054320537.1 → XP_054176512.1  zinc finger and BTB domain-containing protein 32 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2Y4.1 GenPept UniProtKB/Swiss-Prot:Q9Y2Y4

    Gene LinkOut

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