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    GTF2A2 general transcription factor IIA subunit 2 [ Homo sapiens (human) ]

    Gene ID: 2958, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GTF2A2provided by HGNC
    Official Full Name
    general transcription factor IIA subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:4647
    See related
    Ensembl:ENSG00000140307 MIM:600519; AllianceGenome:HGNC:4647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma
    Summary
    Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues See more
    Orthologs
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    Genomic context

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    See GTF2A2 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59638062..59657515, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57439769..57459225, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59930261..59949714, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 117 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:59908775-59909010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9499 Neighboring gene BCL2 interacting protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59981225-59981873 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene RPS3A pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit. Mitsiou DJ, et al. Mol Cell, 2000 Sep. PMID 11030333
    2. The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter. Kuhlman TC, et al. Mol Cell Biol, 1999 Mar. PMID 10022900, Free PMC Article
    3. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. DeJong J, et al. Genes Dev, 1993 Nov. PMID 8224848
    4. A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner. Wang J, et al. J Biol Chem, 2017 Jul 14. PMID 28539359, Free PMC Article
    5. p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction. Xing J, et al. Mol Cell Biol, 2001 Jun. PMID 11340159, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300)
      Title: A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.
    2. transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
      Title: Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation factor IIA subunit 2
    Names
    TFIIA gamma subunit
    TFIIA p12 subunit
    general transcription factor IIA 2
    general transcription factor IIA, 2, 12kDa
    transcription initiation factor IIA gamma chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320929.2 → NP_001307858.1  transcription initiation factor IIA subunit 2

      Status: VALIDATED

      Source sequence(s)
      AC092755, BX099306, HY002503, HY036972
      Consensus CDS
      CCDS10173.1
      UniProtKB/Swiss-Prot
      A8MYQ7, P52657, Q6FGB5
      UniProtKB/TrEMBL
      B2R506
      Related
      ENSP00000379373.1, ENST00000396061.5
      Conserved Domains (1) summary
      COG5123
      Location:3 → 103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

    2. NM_001320930.2 → NP_001307859.1  transcription initiation factor IIA subunit 2

      Status: VALIDATED

      Source sequence(s)
      AC092755, BX099306, CB156109
      Consensus CDS
      CCDS10173.1
      UniProtKB/Swiss-Prot
      A8MYQ7, P52657, Q6FGB5
      UniProtKB/TrEMBL
      B2R506
      Related
      ENSP00000379375.1, ENST00000396063.5
      Conserved Domains (1) summary
      COG5123
      Location:3 → 103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

    3. NM_004492.3 → NP_004483.1  transcription initiation factor IIA subunit 2

      See identical proteins and their annotated locations for NP_004483.1

      Status: VALIDATED

      Source sequence(s)
      AK312015, BC000287, CV572751, DB531003
      Consensus CDS
      CCDS10173.1
      UniProtKB/Swiss-Prot
      A8MYQ7, P52657, Q6FGB5
      UniProtKB/TrEMBL
      B2R506
      Related
      ENSP00000379372.2, ENST00000396060.7
      Conserved Domains (1) summary
      COG5123
      Location:3 → 103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      59638062..59657515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      57439769..57459225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52657.1 GenPept UniProtKB/Swiss-Prot:P52657

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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