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    Arhgef19 Rho guanine nucleotide exchange factor 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362648, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arhgef19provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 19provided by RGD
    Primary source
    RGD:1304766
    See related
    Ensembl:ENSRNOG00000047967 AllianceGenome:RGD:1304766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity and regulation of actin cytoskeleton organization. Predicted to act upstream of or within positive regulation of GTPase activity and wound healing. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 41.1), Kidney (RPKM 11.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef19 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158818840..158837196)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153536038..153554203)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159754954..159773699)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487028 Neighboring gene F-box protein 42 Neighboring gene ciliogenesis and planar polarity effector 2-like Neighboring gene uncharacterized LOC108351054 Neighboring gene ciliogenesis and planar polarity effector complex subunit 2 Neighboring gene Eph receptor A2 Neighboring gene ribosomal protein S27a, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Caddy J, et al. Dev Cell, 2010 Jul 20. PMID 20643356, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 19
    Names
    Rho guanine nucleotide exchange factor (GEF) 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108692.1 → NP_001102162.1  rho guanine nucleotide exchange factor 19

      See identical proteins and their annotated locations for NP_001102162.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ITS3, D4A646
      Related
      ENSRNOP00000061876.3, ENSRNOT00000067574.4
      Conserved Domains (4) summary
      cd01221
      Location:666 → 792
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:679 → 786
      PH; PH domain
      pfam00621
      Location:468 → 645
      RhoGEF; RhoGEF domain
      cl17036
      Location:805 → 859
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158818840..158837196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764270.4 → XP_008762492.1  rho guanine nucleotide exchange factor 19 isoform X1

      See identical proteins and their annotated locations for XP_008762492.1

      UniProtKB/TrEMBL
      A0A8I6ALI5, A6ITS4
      Related
      ENSRNOP00000093983.1
      Conserved Domains (4) summary
      cd01221
      Location:617 → 743
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:630 → 737
      PH; PH domain
      pfam00621
      Location:419 → 596
      RhoGEF; RhoGEF domain
      cl17036
      Location:756 → 810
      SH3; Src Homology 3 domain superfamily

    2. XM_008764272.4 → XP_008762494.1  rho guanine nucleotide exchange factor 19 isoform X2

      See identical proteins and their annotated locations for XP_008762494.1

      UniProtKB/TrEMBL
      A6ITS5
      Conserved Domains (3) summary
      cd01221
      Location:584 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:386 → 562
      RhoGEF; RhoGEF domain
      cl17036
      Location:723 → 777
      SH3; Src Homology 3 domain superfamily

    3. XM_039110425.2 → XP_038966353.1  rho guanine nucleotide exchange factor 19 isoform X2

      UniProtKB/TrEMBL
      A6ITS5
      Conserved Domains (3) summary
      cd01221
      Location:584 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:386 → 562
      RhoGEF; RhoGEF domain
      cl17036
      Location:723 → 777
      SH3; Src Homology 3 domain superfamily

    4. XM_017593525.3 → XP_017449014.1  rho guanine nucleotide exchange factor 19 isoform X2

      UniProtKB/TrEMBL
      A6ITS5
      Conserved Domains (3) summary
      cd01221
      Location:584 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:386 → 562
      RhoGEF; RhoGEF domain
      cl17036
      Location:723 → 777
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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