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    Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117104, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ppp2r2aprovided by RGD
    Official Full Name
    protein phosphatase 2, regulatory subunit B, alphaprovided by RGD
    Primary source
    RGD:620919
    See related
    Ensembl:ENSRNOG00000011158 AllianceGenome:RGD:620919
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein phosphatase 2A binding activity and tau protein binding activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to act upstream of or within response to morphine. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and glutamatergic synapse. Orthologous to human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 321.0), Thymus (RPKM 109.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r2a in Genome Data Viewer
    Location:
    15p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (45380142..45439428, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (41204659..41263924, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (43673958..43733182, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene PNMA family member 2 Neighboring gene BCL2 interacting protein 3 like Neighboring gene uncharacterized LOC102555410 Neighboring gene uncharacterized LOC134482137 Neighboring gene large ribosomal subunit protein eL6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit. Horowitz B, et al. J Biol Chem, 2013 May 10. PMID 23530045, Free PMC Article
    2. Effect of PP-2A on neurite outgrowth in neuronal cells. Liu D, et al. In Vitro Cell Dev Biol Anim, 2010 Sep. PMID 20585893
    3. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. Pallas DC, et al. J Virol, 1992 Feb. PMID 1370560, Free PMC Article
    4. Influence of hypertonic-hyperoncotic solution and furosemide on canine hydrostatic pulmonary oedema resorption. Wickerts CJ, et al. J Physiol, 1992 Dec. PMID 1302272, Free PMC Article
    5. β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation. Weeks KL, et al. J Am Heart Assoc, 2017 Mar 25. PMID 28343149, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta-AR stimulation induces HDAC5 nuclear accumulation in cardiomyocytes by a mechanism that is protein kinase A-dependent but requires B55alpha-PP2A-mediated dephosphorylation of Ser259/Ser498.
      Title: β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.
    2. Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition
      Title: The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition.
    3. Fibroblast growth factor 1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding with retinoblastoma-like 1 (p107) dephosphorylation.
      Title: Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.
    4. A functional significance to the alpha1, alpha2 helices of B55alpha, the binding site defined by these helices could contribute to interactions between PP2A and some of its cellular regulators.
      Title: Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit.
    5. these results indicated that PP-2A may be an important positive regulator in neurite outgrowth.
      Title: Effect of PP-2A on neurite outgrowth in neuronal cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to morphine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    NP_446451.1
    XP_008768954.1
    XP_038948885.1
    XP_063129985.1
    XP_063129986.1
    XP_063129987.1
    XP_063129988.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053999.2 → NP_446451.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

      See identical proteins and their annotated locations for NP_446451.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128731
      UniProtKB/Swiss-Prot
      A1A5M9, O35512, P36876, P36878
      UniProtKB/TrEMBL
      A0A8I6AVF8, A6K6P0
      Related
      ENSRNOP00000015318.5, ENSRNOT00000015318.7
      Conserved Domains (2) summary
      COG5170
      Location:7 → 442
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:31 → 79
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      45380142..45439428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273917.1 → XP_063129987.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

      UniProtKB/TrEMBL
      A0A8I6AVF8

    2. XM_063273916.1 → XP_063129986.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I6AVF8

    3. XM_063273915.1 → XP_063129985.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I6AVF8

    4. XM_063273918.1 → XP_063129988.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A6K6P2

    5. XM_039092957.1 → XP_038948885.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A6K6P2
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    6. XM_008770732.4 → XP_008768954.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      See identical proteins and their annotated locations for XP_008768954.1

      UniProtKB/TrEMBL
      A6K6P2
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36876.1 GenPept UniProtKB/Swiss-Prot:P36876

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