Cdkn2c cyclin-dependent kinase inhibitor 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdkn2cprovided by RGD
Official Full Name: cyclin-dependent kinase inhibitor 2Cprovided by RGD
Primary source: RGD:2325
See related: Ensembl:ENSRNOG00000008956 AllianceGenome:RGD:2325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p18
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 174.6), Spleen (RPKM 105.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (129639736..129645564, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (124411123..124416278, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (129347731..129352886, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

posttranscriptional regulation
Title: Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Lev19 (e-PCR)
- UniSTS:239712

PMC141153P1 (e-PCR)
- UniSTS:270994

PMC141153P2 (e-PCR)
- UniSTS:270995

AI169557 (e-PCR)
- UniSTS:250332

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 4 inhibitor C

Names: cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429663.1 → NP_001416592.1 cyclin-dependent kinase 4 inhibitor C

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4
NM_001429664.1 → NP_001416593.1 cyclin-dependent kinase 4 inhibitor C

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4
NM_131902.5 → NP_571977.1 cyclin-dependent kinase 4 inhibitor C

See identical proteins and their annotated locations for NP_571977.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JYZ6, A6JYZ7, Q8R5G3, Q8R5G4

Related

ENSRNOP00000012088.4, ENSRNOT00000012088.8

Conserved Domains (4) summary

cd00204
Location:37 → 156

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:9 → 100

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:89 → 144

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:37 → 67

ANK; ANK repeat [structural motif]