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    Zfr zinc finger RNA binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365703, updated on 2-May-2024

    Summary

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    Official Symbol
    Zfrprovided by RGD
    Official Full Name
    zinc finger RNA binding proteinprovided by RGD
    Primary source
    RGD:1311890
    See related
    Ensembl:ENSRNOG00000011627 AllianceGenome:RGD:1311890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be located in chromosome; cytoplasm; and nucleus. Orthologous to human ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 418.9), Adrenal (RPKM 240.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62864333..62927377)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61137611..61200322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62150251..62213048)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101085 Neighboring gene uncharacterized LOC134485601 Neighboring gene U6 spliceosomal RNA Neighboring gene myotubularin related protein 12 Neighboring gene uncharacterized LOC134485602 Neighboring gene uncharacterized LOC120101086

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. Elvira G, et al. J Neurochem, 2006 Jan. PMID 16277607
    2. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270972.1 → NP_001257901.1  zinc finger RNA-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q562A2
      UniProtKB/TrEMBL
      A0A0H2UHJ5
      Related
      ENSRNOP00000016196.6, ENSRNOT00000016196.7
      Conserved Domains (4) summary
      smart00572
      Location:784 → 1038
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:382 → 551
      PHA03255; BDLF3; Provisional
      smart00451
      Location:581 → 612
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:333 → 355
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      62864333..62927377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282250.1 → XP_063138320.1  zinc finger RNA-binding protein isoform X2

    2. XM_039102742.2 → XP_038958670.1  zinc finger RNA-binding protein isoform X5

      UniProtKB/Swiss-Prot
      Q562A2
      UniProtKB/TrEMBL
      A6KJQ3
      Conserved Domains (4) summary
      smart00572
      Location:720 → 974
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:350 → 487
      PHA03255; BDLF3; Provisional
      smart00451
      Location:517 → 548
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:520 → 542
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006232054.5 → XP_006232116.1  zinc finger RNA-binding protein isoform X3

      UniProtKB/Swiss-Prot
      Q562A2
      UniProtKB/TrEMBL
      A0A0G2K6C9
      Related
      ENSRNOP00000073762.2
      Conserved Domains (4) summary
      smart00572
      Location:747 → 1001
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:345 → 514
      PHA03255; BDLF3; Provisional
      smart00451
      Location:544 → 575
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:296 → 318
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_017590988.3 → XP_017446477.1  zinc finger RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q562A2
      UniProtKB/TrEMBL
      A0A8L2RAI7
      Related
      ENSRNOP00000075053.2
      Conserved Domains (4) summary
      smart00572
      Location:792 → 1046
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:390 → 559
      PHA03255; BDLF3; Provisional
      smart00451
      Location:589 → 620
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:341 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_017590989.3 → XP_017446478.1  zinc finger RNA-binding protein isoform X4

      UniProtKB/Swiss-Prot
      Q562A2
      Conserved Domains (4) summary
      smart00572
      Location:728 → 982
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:358 → 495
      PHA03255; BDLF3; Provisional
      smart00451
      Location:525 → 556
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:528 → 550
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_063282251.1 → XP_063138321.1  zinc finger RNA-binding protein isoform X6

    RNA

    1. XR_010063629.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q562A2.2 GenPept UniProtKB/Swiss-Prot:Q562A2

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