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    AGO2 argonaute RISC catalytic component 2 [ Bos taurus (cattle) ]

    Gene ID: 404130, updated on 5-Mar-2024

    Summary

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    Official Symbol
    AGO2provided by VGNC
    Official Full Name
    argonaute RISC catalytic component 2provided by VGNC
    Primary source
    VGNC:VGNC:50167
    See related
    BGD:BT14102; Ensembl:ENSBTAG00000001579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    EIF2C2
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See AGO2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (3100810..3138228)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 2 Neighboring gene uncharacterized LOC112449596 Neighboring gene uncharacterized LOC132342171 Neighboring gene uncharacterized LOC132342172 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene microRNA mir-12027

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables endoribonuclease activity, cleaving siRNA-paired mRNA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein argonaute-2
    Names
    argonaute 2, RISC catalytic component
    eukaryotic translation initiation factor 2C, 2
    NP_991363.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205794.1 → NP_991363.1  protein argonaute-2

      See identical proteins and their annotated locations for NP_991363.1

      Status: PROVISIONAL

      Source sequence(s)
      AY533678
      UniProtKB/Swiss-Prot
      Q6QME8
      UniProtKB/TrEMBL
      A0A3Q1MM22
      Related
      ENSBTAP00000072138.2, ENSBTAT00000078414.2
      Conserved Domains (5) summary
      PLN03202
      Location:26 → 859
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:228 → 348
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:393 → 818
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:178 → 227
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:29 → 167
      ArgoN; N-terminal domain of argonaute

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3100810..3138228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QME8.1 GenPept UniProtKB/Swiss-Prot:Q6QME8

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