Cd300a Cd300a molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd300aprovided by RGD
Official Full Name: Cd300a moleculeprovided by RGD
Primary source: RGD:1583719
See related: Ensembl:ENSRNOG00000057058 AllianceGenome:RGD:1583719
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CLM-8
Summary: Predicted to enable phosphatase binding activity; phospholipid binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including negative regulation of leukocyte activation; regulation of protein modification process; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of secretion by cell; receptor-mediated endocytosis; and serotonin secretion by mast cell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human CD300A (CD300a molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 187.1), Liver (RPKM 39.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (100428826..100441693)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (99929801..99942674)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (103437978..103451170)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129637 (e-PCR)
- UniSTS:212934

RH129639 (e-PCR)
- UniSTS:212936

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of serotonin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serotonin secretion by mast cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CMRF35-like molecule 8

Names: CD300 antigen-like family member A; immune inhibitory receptor CD300A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205348.1 → NP_001192277.1 CMRF35-like molecule 8 precursor

See identical proteins and their annotated locations for NP_001192277.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

A2TGX5

UniProtKB/TrEMBL

A0A0G2K2W8, A6HKJ6

Related

ENSRNOP00000072406.2, ENSRNOT00000085262.2

Conserved Domains (3) summary

cd05716
Location:33 → 127

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:30 → 129

IG_like; Immunoglobulin like

pfam15330
Location:198 → 276

SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

100428826..100441693

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086656.2 → XP_038942584.1 CMRF35-like molecule 8 isoform X1

Conserved Domains (1) summary

cd05716
Location:27 → 128

IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins