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    Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase [ Mus musculus (house mouse) ]

    Gene ID: 93843, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pnckprovided by MGI
    Official Full Name
    pregnancy upregulated non-ubiquitously expressed CaM kinaseprovided by MGI
    Primary source
    MGI:MGI:1347357
    See related
    Ensembl:ENSMUSG00000002012 AllianceGenome:MGI:1347357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Punc; Bstk3; Camk1b; CaMKlb2; caMKlb1; CaMKIbeta2
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PNCK (pregnancy up-regulated nonubiquitous CaM kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 58.1), bladder adult (RPKM 49.0) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A7.3; X 37.38 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72699598..72703723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73655992..73660117, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47347 Neighboring gene dual specificity phosphatase 9 Neighboring gene predicted gene, 52444 Neighboring gene STARR-seq mESC enhancer starr_47348 Neighboring gene predicted gene, 32261 Neighboring gene solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Neighboring gene STARR-seq mESC enhancer starr_47349 Neighboring gene B cell receptor associated protein 31 Neighboring gene STARR-positive B cell enhancer ABC_E11048 Neighboring gene ATP-binding cassette, sub-family D member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system. Ueda T, et al. J Neurochem, 1999 Nov. PMID 10537072
    2. Mammary gland development, reproductive history, and breast cancer risk. Chodosh LA, et al. Cancer Res, 1999 Apr 1. PMID 10197594
    3. Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase. Gardner HP, et al. Genomics, 2000 Jan 15. PMID 10673339
    4. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Kamata A, et al. Neurosci Res, 2007 Jan. PMID 17056143
    5. Pax1 and Pax9 synergistically regulate vertebral column development. Peters H, et al. Development, 1999 Dec. PMID 10556064

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1B
    Names
    caM kinase I beta
    caM kinase IB
    caM-KI beta
    caMKI-beta
    calcium/calmodulin-dependent protein kinase 1, beta
    pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog
    NP_001186280.1
    NP_001186281.1
    NP_036170.1
    XP_006528407.1
    XP_011245994.1
    XP_030107390.1
    XP_030107391.1
    XP_036018022.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199351.1 → NP_001186280.1  calcium/calmodulin-dependent protein kinase type 1B

      See identical proteins and their annotated locations for NP_001186280.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AF181984, AK134665, CD776443, CX243772
      Consensus CDS
      CCDS30207.1
      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Related
      ENSMUSP00000110117.2, ENSMUST00000114473.8
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    2. NM_001199352.1 → NP_001186281.1  calcium/calmodulin-dependent protein kinase type 1B

      See identical proteins and their annotated locations for NP_001186281.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK158755, BC051996, CD776443
      Consensus CDS
      CCDS30207.1
      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Related
      ENSMUSP00000110116.2, ENSMUST00000114472.8
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    3. NM_012040.3 → NP_036170.1  calcium/calmodulin-dependent protein kinase type 1B

      See identical proteins and their annotated locations for NP_036170.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AF181984, CD776443, CX243772
      Consensus CDS
      CCDS30207.1
      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Related
      ENSMUSP00000002087.8, ENSMUST00000002087.14
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72699598..72703723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247692.3 → XP_011245994.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

      See identical proteins and their annotated locations for XP_011245994.1

      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    2. XM_036162129.1 → XP_036018022.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/TrEMBL
      Q3UYI0
      Conserved Domains (1) summary
      cl21453
      Location:2 → 258
      PKc_like; Protein Kinases, catalytic domain

    3. XM_030251530.2 → XP_030107390.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    4. XM_006528344.5 → XP_006528407.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

      See identical proteins and their annotated locations for XP_006528407.1

      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    5. XM_030251531.1 → XP_030107391.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

      UniProtKB/Swiss-Prot
      Q80W07, Q9QYK9
      UniProtKB/TrEMBL
      Q3TYC1, Q3UYI0
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    RNA

    1. XR_003953034.1 RNA Sequence

    2. XR_001782761.2 RNA Sequence

    3. XR_003953032.1 RNA Sequence

    4. XR_003953033.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYK9.1 GenPept UniProtKB/Swiss-Prot:Q9QYK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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