Cpn1 carboxypeptidase N subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpn1provided by RGD
Official Full Name: carboxypeptidase N subunit 1provided by RGD
Primary source: RGD:70931
See related: Ensembl:ENSRNOG00000013439 AllianceGenome:RGD:70931
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cpn
Summary: Enables carboxypeptidase activity. Involved in bradykinin catabolic process; proteolysis; and response to glucocorticoid. Located in extracellular space. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 414.2), Kidney (RPKM 101.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252793786..252822675, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242844575..242873465, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263733887..263762758, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Cpn1 (e-PCR), detects polymorphism
- UniSTS:516131

RH133012 (e-PCR)
- UniSTS:216295

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxypeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bradykinin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carboxypeptidase N catalytic chain

Names: carboxypeptidase N catalytic chain-like; carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1, 50kD

NP_445978.1

EC 3.4.17.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053526.2 → NP_445978.1 carboxypeptidase N catalytic chain precursor

See identical proteins and their annotated locations for NP_445978.1

Status: PROVISIONAL

Source sequence(s)

BC088124

UniProtKB/Swiss-Prot

Q9EQV8

UniProtKB/TrEMBL

A0A8I5ZTU6, A6JHE4

Related

ENSRNOP00000018221.6, ENSRNOT00000018221.8

Conserved Domains (2) summary

cd11308
Location:341 → 415

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cl11393
Location:25 → 337

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins