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    Ncam2 neural cell adhesion molecule 2 [ Mus musculus (house mouse) ]

    Gene ID: 17968, updated on 12-May-2024

    Summary

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    Official Symbol
    Ncam2provided by MGI
    Official Full Name
    neural cell adhesion molecule 2provided by MGI
    Primary source
    MGI:MGI:97282
    See related
    Ensembl:ENSMUSG00000022762 AllianceGenome:MGI:97282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ocam; RNCAM; Ncam-2
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in cell adhesion. Located in axon. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 3.2), frontal lobe adult (RPKM 3.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C3.3; 16 45.89 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (80997501..81425549)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (81200697..81624290)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41327 Neighboring gene FK506 binding protein 1a, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_41328 Neighboring gene STARR-seq mESC enhancer starr_41329 Neighboring gene STARR-seq mESC enhancer starr_41331 Neighboring gene STARR-seq mESC enhancer starr_41333 Neighboring gene STARR-seq mESC enhancer starr_41334 Neighboring gene predicted gene, 49558 Neighboring gene cell division cycle 5-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization. Parcerisas A, et al. Int J Mol Sci, 2021 Jul 9. PMID 34299022, Free PMC Article
    2. Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation. Sheng L, et al. Cereb Cortex, 2019 Apr 1. PMID 29522129
    3. Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. Sheng L, et al. J Neurosci, 2015 Jan 28. PMID 25632147, Free PMC Article
    4. Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli. Borisovska M, et al. J Physiol, 2011 Apr 15. PMID 21486802, Free PMC Article
    5. Identification of a novel neural cell adhesion molecule-related gene with a potential role in selective axonal projection. Alenius M, et al. J Biol Chem, 1997 Oct 17. PMID 9334170

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).
      Title: Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).
    2. Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits.
      Title: Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits.
    3. The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.
      Title: The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.
    4. NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
      Title: NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
    5. New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.
      Title: New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.
    6. Study demonstrates that an increase in NCAM2 levels results in increased instability of dendritic protrusions and reduced conversion of protrusions to dendritic spines in mouse cortical neurons.
      Title: Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.
    7. Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss.
      Title: Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.
    8. These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling
      Title: OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor.
    9. This study identified the cell adhesion molecule NCAM2 as a new regulator of filopodial formation and neurite branching.
      Title: Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels.
    10. Two novel Mmatrix metallopeptidase 9 targets were identified: synaptic cell adhesion molecule-2 and collapsin response mediator protein-2
      Title: Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neural cell adhesion molecule 2
    Names
    N-CAM-2
    R4B12 antigen
    neural cell adhesion molecule RB-8
    olfactory axon cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113208.1 → NP_001106679.1  neural cell adhesion molecule 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001106679.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AF016620, AW121550, BB663005, BC119027, BM933307
      Consensus CDS
      CCDS49888.1
      UniProtKB/Swiss-Prot
      O35136, O35962, Q0VF23
      Related
      ENSMUSP00000063468.4, ENSMUST00000067602.5
      Conserved Domains (7) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      smart00408
      Location:414 → 482
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:308 → 395
      IG_like; Immunoglobulin like
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:22 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      cl11960
      Location:300 → 397
      Ig; Immunoglobulin domain

    2. NM_010954.4 → NP_035084.1  neural cell adhesion molecule 2 isoform b precursor

      See identical proteins and their annotated locations for NP_035084.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC123849, AW121550, BC119027
      Consensus CDS
      CCDS28281.1
      UniProtKB/Swiss-Prot
      O35136
      Related
      ENSMUSP00000049390.8, ENSMUST00000037785.14
      Conserved Domains (7) summary
      cd05866
      Location:21 → 112
      Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
      smart00408
      Location:414 → 482
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:308 → 395
      IG_like; Immunoglobulin like
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:22 → 111
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      cl11960
      Location:300 → 397
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      80997501..81425549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159816.1 → XP_036015709.1  neural cell adhesion molecule 2 isoform X2

      UniProtKB/TrEMBL
      Q3V1M4
      Conserved Domains (5) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:300 → 305
      Ig; Ig strand A [structural motif]
      cd05866
      Location:21 → 113
      IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
      cd20970
      Location:209 → 298
      IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
      cl11960
      Location:300 → 348
      Ig; Immunoglobulin domain

    2. XM_036159815.1 → XP_036015708.1  neural cell adhesion molecule 2 isoform X1

      Conserved Domains (5) summary
      cd00063
      Location:285 → 377
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:383 → 467
      fn3; Fibronectin type III domain
      pfam13927
      Location:190 → 268
      Ig_3; Immunoglobulin domain
      cd00096
      Location:89 → 94
      Ig; Ig strand A [structural motif]
      cl11960
      Location:89 → 186
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35136.1 GenPept UniProtKB/Swiss-Prot:O35136

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