U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dusp13b dual specificity phosphatase 13B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361002, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dusp13bprovided by RGD
    Official Full Name
    dual specificity phosphatase 13Bprovided by RGD
    Primary source
    RGD:1359712
    See related
    AllianceGenome:RGD:1359712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dusp13
    Summary
    Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and negative regulation of MAPK cascade. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human DUSP13 (dual specificity phosphatase 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 231.7), Testes (RPKM 93.2) and 1 other tissue See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dusp13b in Genome Data Viewer
    Location:
    15p16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2616761..2624434)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2567432..2575105)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2524435..2541734)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene voltage-dependent anion channel 2 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene uncharacterized LOC108352868 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC120096899 Neighboring gene dual specificity phosphatase 29 Neighboring gene uncharacterized LOC108352871

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Nakamura K, et al. Biochem J, 1999 Dec 15. PMID 10585869, Free PMC Article
    2. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. Chen HH, et al. J Biol Chem, 2004 Oct 1. PMID 15252030
    3. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789
    4. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC94474

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    testis and skeletal muscle-specific dual specificity phosphatase
    Names
    dual specificity phosphatase 13
    dual specificity protein phosphatase 13
    NP_001007007.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007006.1 → NP_001007007.1  testis and skeletal muscle-specific dual specificity phosphatase

      See identical proteins and their annotated locations for NP_001007007.1

      Status: VALIDATED

      Source sequence(s)
      BC083646
      UniProtKB/TrEMBL
      Q5XIN2
      Conserved Domains (1) summary
      cl28904
      Location:28 → 191
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      2616761..2624434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools