Cacna1c calcium voltage-gated channel subunit alpha1 C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna1cprovided by RGD
Official Full Name: calcium voltage-gated channel subunit alpha1 Cprovided by RGD
Primary source: RGD:2245
See related: Ensembl:ENSRNOG00000007090 AllianceGenome:RGD:2245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RATIVS302
Summary: Enables several functions, including high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and transmembrane transporter binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Located in several cellular components, including T-tubule; postsynaptic density; and synaptic membrane. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 239.6), Uterus (RPKM 92.8) and 5 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q42

Exon count:: 54

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (153431169..154051932, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (151764138..152379454, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (150635808..151270790, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats.
Title: Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats.
Rapid Pacing Decreases L-type Ca[2+] Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes.
Title: Rapid Pacing Decreases L-type Ca(2+) Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes.
Characterisation of the neural basis underlying appetitive extinction & renewal in Cacna1c rats.
Title: Characterisation of the neural basis underlying appetitive extinction & renewal in Cacna1c rats.
Neuroprotective effects of aripiprazole in stress-induced depressive-like behavior: Possible role of CACNA1C.
Title: Neuroprotective effects of aripiprazole in stress-induced depressive-like behavior: Possible role of CACNA1C.
The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells.
Title: The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells.
Sex differences in the acoustic features of social play-induced 50-kHz ultrasonic vocalizations: A detailed spectrographic analysis in wild-type Sprague-Dawley and Cacna1c haploinsufficient rats.
Title: Sex differences in the acoustic features of social play-induced 50-kHz ultrasonic vocalizations: A detailed spectrographic analysis in wild-type Sprague-Dawley and Cacna1c haploinsufficient rats.
Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation.
Title: Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation.
Antenatal Hypoxia Affects Pulmonary Artery Contractile Functions via Downregulating L-type Ca(2+) Channels Subunit Alpha1 C in Adult Male Offspring.
Title: Antenatal Hypoxia Affects Pulmonary Artery Contractile Functions via Downregulating L-type Ca(2+) Channels Subunit Alpha1 C in Adult Male Offspring.
Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.
Title: Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.
Zn(2+) ions inhibit gene transcription following stimulation of the Ca(2+) channels Cav1.2 and TRPM3.
Title: Zn(2+) ions inhibit gene transcription following stimulation of the Ca(2+) channels Ca(v)1.2 and TRPM3.

Submit: New GeneRIF Correction See all GeneRIFs (118)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D4Rat137 (e-PCR)
- UniSTS:118813

RH138902 (e-PCR)
- UniSTS:220989

Cacna1c (e-PCR), detects polymorphism
- UniSTS:461905

BE119369 (e-PCR)
- UniSTS:249175

RH144587 (e-PCR)
- UniSTS:233832

UniSTS:495979 (e-PCR)
- UniSTS:495979

Cacna1c (e-PCR), detects polymorphism
- UniSTS:495979

D4MGH30 (e-PCR)
- UniSTS:120437

UniSTS:259196 (e-PCR)
- UniSTS:259196

Cacna1c (e-PCR), detects polymorphism
- UniSTS:259196

AU027977 (e-PCR)
- UniSTS:112779

D4Arb4 (e-PCR)
- UniSTS:240308

RH144194 (e-PCR)
- UniSTS:233440

BF387868 (e-PCR)
- UniSTS:244454

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables voltage-gated calcium channel activity involved in AV node cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in axon development	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell communication involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in immune system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle contraction involved in micturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of L-type voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in T-tubule	TAS Traceable Author Statement more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
located_in basal pole of outer hair cell	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of caveolar macromolecular signaling complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: voltage-dependent L-type calcium channel subunit alpha-1C

Names: L-type calcium channel alpha-1 subunit; RBC; brain class C; calcium channel, voltage-dependent, L type, alpha 1C subunit; calcium channel, voltage-dependent, alpha 1C subunit; voltage-gated calcium channel subunit alpha Cav1.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012517.2 → NP_036649.2 voltage-dependent L-type calcium channel subunit alpha-1C

Status: VALIDATED

Source sequence(s)

AF394939, DQ538522, JAXUCZ010000004, M67516

UniProtKB/TrEMBL

A0A8I6ANR4

Related

ENSRNOP00000094898.1, ENSRNOT00000106776.1

Conserved Domains (5) summary

pfam00520
Location:1266 → 1517

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1684 → 2117

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1525 → 1588

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:232 → 321

TrbL; TrbL/VirB6 plasmid conjugal transfer protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

153431169..154051932 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285506.1 → XP_063141576.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X25
XM_063285499.1 → XP_063141569.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X18
XM_063285512.1 → XP_063141582.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X31
XM_063285503.1 → XP_063141573.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X22
XM_063285508.1 → XP_063141578.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X27
XM_063285500.1 → XP_063141570.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X19
XM_063285504.1 → XP_063141574.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X23
XM_063285491.1 → XP_063141561.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X10
XM_063285492.1 → XP_063141562.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X11
XM_063285487.1 → XP_063141557.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X6
XM_063285495.1 → XP_063141565.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X14
XM_063285483.1 → XP_063141553.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X2
XM_063285505.1 → XP_063141575.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X24
XM_063285498.1 → XP_063141568.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

UniProtKB/TrEMBL

F1M5G9, Q8VHT3
XM_063285501.1 → XP_063141571.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

UniProtKB/TrEMBL

Q8VHT2
XM_063285507.1 → XP_063141577.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X26
XM_063285497.1 → XP_063141567.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

UniProtKB/TrEMBL

F1LMN0, Q71QJ6
XM_063285502.1 → XP_063141572.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X21
XM_063285493.1 → XP_063141563.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X12
XM_063285496.1 → XP_063141566.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X15
XM_063285489.1 → XP_063141559.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X8
XM_063285490.1 → XP_063141560.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X9
XM_063285488.1 → XP_063141558.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X7
XM_063285485.1 → XP_063141555.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X4
XM_063285486.1 → XP_063141556.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X5
XM_063285482.1 → XP_063141552.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X1
XM_063285484.1 → XP_063141554.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X3
XM_063285494.1 → XP_063141564.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X13
XM_063285509.1 → XP_063141579.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X28
XM_063285510.1 → XP_063141580.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X29
XM_063285511.1 → XP_063141581.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X30