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    Neil1 nei-like DNA glycosylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367090, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Neil1provided by RGD
    Official Full Name
    nei-like DNA glycosylase 1provided by RGD
    Primary source
    RGD:1306077
    See related
    Ensembl:ENSRNOG00000018577 AllianceGenome:RGD:1306077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable catalytic activity, acting on DNA; lyase activity; and protein C-terminus binding activity. Predicted to be involved in base-excision repair; negative regulation of nuclease activity; and response to oxidative stress. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 93.2), Kidney (RPKM 48.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neil1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66446106..66452844, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57550142..57556884, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61817258..61824023, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SIN3 transcription regulator family member A Neighboring gene uncharacterized LOC120094172 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene COMM domain containing 4 Neighboring gene voltage-dependent anion channel 2, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity. Ma H, et al. Toxicol Appl Pharmacol, 2011 Feb 15. PMID 21145906, Free PMC Article
    2. The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. Das A, et al. J Biol Chem, 2007 Sep 7. PMID 17611195
    3. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. Takao M, et al. J Biol Chem, 2002 Nov 1. PMID 12200441
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the spleen aniline-induced oxidative stress is associated with an induction of NEIL1/2.
      Title: Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116267

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 8-like 1
    Names
    endonuclease VIII-like 1
    nei endonuclease VIII-like 1
    NP_001020925.1
    XP_038937801.1
    XP_038937802.1
    XP_063121951.1
    XP_063121952.1
    XP_063121953.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025754.1 → NP_001020925.1  endonuclease 8-like 1

      See identical proteins and their annotated locations for NP_001020925.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099125
      UniProtKB/TrEMBL
      A0A8I6AWQ3, A0A8I6G4B6, A6J4T0, Q4KLM0
      Related
      ENSRNOP00000055440.2, ENSRNOT00000058645.2
      Conserved Domains (3) summary
      PRK10445
      Location:134 → 194
      PRK10445; endonuclease VIII; Provisional
      pfam09292
      Location:252 → 290
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66446106..66452844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265883.1 → XP_063121953.1  endonuclease 8-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4B6

    2. XM_063265881.1 → XP_063121951.1  endonuclease 8-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4B6

    3. XM_063265882.1 → XP_063121952.1  endonuclease 8-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4B6

    4. XM_039081874.2 → XP_038937802.1  endonuclease 8-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AWQ3, A0A8I6G4B6, A6J4T0, Q4KLM0
      Conserved Domains (3) summary
      PRK10445
      Location:134 → 194
      PRK10445; endonuclease VIII; Provisional
      pfam09292
      Location:252 → 290
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    5. XM_039081873.2 → XP_038937801.1  endonuclease 8-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AWQ3, A0A8I6G4B6, A6J4T0, Q4KLM0
      Related
      ENSRNOP00000097715.1
      Conserved Domains (3) summary
      PRK10445
      Location:134 → 194
      PRK10445; endonuclease VIII; Provisional
      pfam09292
      Location:252 → 290
      Neil1-DNA_bind; Endonuclease VIII-like 1, DNA bind
      cl03119
      Location:1 → 127
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    RNA

    1. XR_005487880.2 RNA Sequence

    2. XR_010054008.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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