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    PLAAT5 phospholipase A and acyltransferase 5 [ Homo sapiens (human) ]

    Gene ID: 117245, updated on 6-Jun-2024

    Summary

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    Official Symbol
    PLAAT5provided by HGNC
    Official Full Name
    phospholipase A and acyltransferase 5provided by HGNC
    Primary source
    HGNC:HGNC:24978
    See related
    Ensembl:ENSG00000168004 MIM:611474; AllianceGenome:HGNC:24978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RLP1; iNAT; HRLP5; HRSL5; HRASLS5; PLAAT-5
    Summary
    Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 31.0), fat (RPKM 23.9) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See PLAAT5 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63461404..63491167, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63450660..63480424, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63228876..63258639, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 10 Neighboring gene solute carrier family 22 member 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63202489-63203041 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63203042-63203593 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63215327-63216263 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63216264-63217199 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63219920-63220481 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63220482-63221042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63227984-63228595 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene uncharacterized LOC124902822 Neighboring gene uncharacterized LOC124902684 Neighboring gene NANOG hESC enhancer GRCh37_chr11:63268635-63269162 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63270478-63271148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63277705-63278336 Neighboring gene galectin 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. Jin XH, et al. Biochim Biophys Acta, 2009 Jan. PMID 19000777
    2. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. Jin XH, et al. J Biol Chem, 2007 Feb 9. PMID 17158102
    3. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. Uyama T, et al. J Biol Chem, 2012 Sep 14. PMID 22825852, Free PMC Article
    4. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A and acyltransferase 5
    Names
    Ca(2+)-independent N-acyltransferase
    H-rev107-like protein 5
    HRAS like suppressor family member 5
    HRAS-like suppressor 5
    calcium-independent phosphatidylethanolamine N-acyltransferase
    lecithin-retinol acyltransferase (LRAT)-like protein-1
    phospholipase A/acyltransferase-5
    testicular tissue protein Li 90
    NP_001140200.2
    NP_001140201.2
    NP_473449.2
    XP_011543053.1
    XP_011543054.1
    XP_047282295.1
    XP_047282296.1
    XP_054223588.1
    XP_054223589.1
    XP_054223590.1
    XP_054223591.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146728.2 → NP_001140200.2  phospholipase A and acyltransferase 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1 that results in a frameshift. It encodes isoform 3, which has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AP000484, AP001591
      Consensus CDS
      CCDS53647.1
      UniProtKB/TrEMBL
      B4DY88
      Related
      ENSP00000443873.1, ENST00000539221.5
      Conserved Domains (1) summary
      pfam04970
      Location:142 → 233
      LRAT; Lecithin retinol acyltransferase

    2. NM_001146729.2 → NP_001140201.2  phospholipase A and acyltransferase 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AP000484, AP001591
      Consensus CDS
      CCDS53646.1
      UniProtKB/TrEMBL
      Q8NE88
      Related
      ENSP00000444809.1, ENST00000540857.6
      Conserved Domains (1) summary
      pfam04970
      Location:132 → 235
      LRAT; Lecithin retinol acyltransferase

    3. NM_054108.4 → NP_473449.2  phospholipase A and acyltransferase 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AP000484, AP001591
      Consensus CDS
      CCDS8044.1
      UniProtKB/Swiss-Prot
      B7X6T1, F5GZ87, F5H4Y9, Q96KN8
      UniProtKB/TrEMBL
      Q8NE88
      Related
      ENSP00000301790.4, ENST00000301790.4
      Conserved Domains (1) summary
      pfam04970
      Location:142 → 245
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63461404..63491167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544752.3 → XP_011543054.1  phospholipase A and acyltransferase 5 isoform X2

      Conserved Domains (1) summary
      pfam04970
      Location:57 → 133
      LRAT; Lecithin retinol acyltransferase

    2. XM_011544751.4 → XP_011543053.1  phospholipase A and acyltransferase 5 isoform X1

      UniProtKB/TrEMBL
      Q8NE88
      Conserved Domains (1) summary
      pfam04970
      Location:131 → 234
      LRAT; Lecithin retinol acyltransferase

    3. XM_047426339.1 → XP_047282295.1  phospholipase A and acyltransferase 5 isoform X3

    4. XM_047426340.1 → XP_047282296.1  phospholipase A and acyltransferase 5 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63450660..63480424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367614.1 → XP_054223589.1  phospholipase A and acyltransferase 5 isoform X2

    2. XM_054367613.1 → XP_054223588.1  phospholipase A and acyltransferase 5 isoform X1

      UniProtKB/TrEMBL
      Q8NE88

    3. XM_054367615.1 → XP_054223590.1  phospholipase A and acyltransferase 5 isoform X3

    4. XM_054367616.1 → XP_054223591.1  phospholipase A and acyltransferase 5 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KN8.2 GenPept UniProtKB/Swiss-Prot:Q96KN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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