TP53I3 tumor protein p53 inducible protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TP53I3provided by HGNC
Official Full Name: tumor protein p53 inducible protein 3provided by HGNC
Primary source: HGNC:HGNC:19373
See related: Ensembl:ENSG00000115129 MIM:605171; AllianceGenome:HGNC:19373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PIG3
Summary: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression: Broad expression in esophagus (RPKM 29.3), small intestine (RPKM 17.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (24077433..24084834, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (24112112..24119520, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (24300303..24307704, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of PIG3 is frequently reduced in gastric cancer (GC) tissue, and PIG3 suppressed human GC growth through p53- mediated apoptosis; PIG3 may act as a potential diagnostic marker and a potential therapeutic target of GC
Title: PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis.
Study found that PIG3 expression was positively associated with lymph node metastasis from lung adenocarcinoma (LUAD) but not from lung squamous cell carcinoma (LUSC). Further data revealed a role for PIG3 in inducing LUAD metastasis, and its role as a new FAK regulator, suggesting that it could be considered as a novel prognostic biomarker.
Title: p53-inducible gene 3 promotes cell migration and invasion by activating the FAK/Src pathway in lung adenocarcinoma.
Results revealed that PIG3 expression levels positively correlated with poor prognosis of non-small cell lung cancer (NSCLC) patients and indicate that PIG3 promotes NSCLC progression.
Title: PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients.
Data suggest that PIG3 was involved in HIF-1alpha regulation, and indicate a signaling pathway of PIG3/HIF-1alpha in the regulation of cell migration in renal cell carcinoma.
Title: Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells.
our data suggest that high expression of p53-inducible gene 3 is significant for glioblastoma inhibition and p53-inducible gene 3 independently indicates good prognosis in patients, which might be a novel prognostic biomarker or potential therapeutic target in glioblastoma.
Title: Suppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosis.
Data indicate that knockdown of p53-induced gene 3 (PIG-3) expression by small interfering RNA (siRNA) treatment can inhibit the generation of reactive oxygen species (ROS).
Title: Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway.
The results suggested that PIG3 plays an oncogenic role in PTC via the regulation of the PI3K/AKT/PTEN pathway and support the exploration of PIG3 as a novel biomarker for patients with papillary thyroid carcinoma
Title: PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway.
PIG3, which functions in DNA damage repair, uses an unexpected catalytic mechanism to suppress Rho-ROCK activity and impair tumor invasion in vivo. This regulation was suppressed by antioxidants.
Title: Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
prohibitin and prohibiton (PHB2) contribute to PIG3-mediated apoptosis by binding to the PIG3 promoter (TGYCC)15 motif
Title: Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.
study provides evidence that the variant genotypes of (TGYCC)n repeats in the PIG3 promoter are functional and associated with risk of squamous cell carcinoma of the head and neck in a non-Hispanic white population
Title: Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NADPH binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH binding	IDA Inferred from Direct Assay more info	PubMed
enables NADPH:quinone reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADPH:quinone reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables quinone binding	IBA Inferred from Biological aspect of Ancestor more info
enables quinone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: quinone oxidoreductase PIG3

Names: NADPH:quinone reductase PIG3; p53-induced gene 3 protein; quinone oxidoreductase homolog

NP_001193731.1

EC 1.6.5.5

NP_004872.2

EC 1.6.5.5

NP_671713.1

EC 1.6.5.5

XP_006712213.1

EC 1.6.5.5

XP_024309017.1

EC 1.6.5.5

XP_054200634.1

EC 1.6.5.5

XP_054200635.1

EC 1.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029715.1 RefSeqGene

Range

5382..12783

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001206802.2 → NP_001193731.1 quinone oxidoreductase PIG3 isoform 2

See identical proteins and their annotated locations for NP_001193731.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks a coding exon in the 3' region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. This variant lacks the 5'-most non-coding exon because of alternate splicing, the extension at the 5' end is uncertain.

Source sequence(s)

AK223382, AY371700, CN285566

Consensus CDS

CCDS56112.1

UniProtKB/TrEMBL

H7BZH6

Related

ENSP00000384414.1, ENST00000407482.5

Conserved Domains (1) summary

cl16912
Location:1 → 205

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
NM_004881.5 → NP_004872.2 quinone oxidoreductase PIG3 isoform 1

See identical proteins and their annotated locations for NP_004872.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).

Source sequence(s)

AK223382, BT007149, CN285566

Consensus CDS

CCDS1708.1

UniProtKB/Swiss-Prot

D6W533, O14679, O14685, Q38G78, Q53FA7, Q6JLE7, Q9BWB8

Related

ENSP00000238721.4, ENST00000238721.9

Conserved Domains (1) summary

cd05276
Location:1 → 328

p53_inducible_oxidoreductase; PIG3 p53-inducible quinone oxidoreductase
NM_147184.4 → NP_671713.1 quinone oxidoreductase PIG3 isoform 1

See identical proteins and their annotated locations for NP_671713.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5'UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC000474, CN285566, DB032484

Consensus CDS

CCDS1708.1

UniProtKB/Swiss-Prot

D6W533, O14679, O14685, Q38G78, Q53FA7, Q6JLE7, Q9BWB8

Related

ENSP00000337834.4, ENST00000335934.8

Conserved Domains (1) summary

cd05276
Location:1 → 328

p53_inducible_oxidoreductase; PIG3 p53-inducible quinone oxidoreductase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

24077433..24084834 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006712150.3 → XP_006712213.1 quinone oxidoreductase PIG3 isoform X1

See identical proteins and their annotated locations for XP_006712213.1

UniProtKB/TrEMBL

H7BZH6

Conserved Domains (1) summary

cl16912
Location:1 → 205

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
XM_024453249.2 → XP_024309017.1 quinone oxidoreductase PIG3 isoform X2

UniProtKB/TrEMBL

B4DMQ7

Conserved Domains (1) summary

cl16912
Location:48 → 239

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

24112112..24119520 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344659.1 → XP_054200634.1 quinone oxidoreductase PIG3 isoform X1
XM_054344660.1 → XP_054200635.1 quinone oxidoreductase PIG3 isoform X2

UniProtKB/TrEMBL

B4DMQ7