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    PAQR3 progestin and adipoQ receptor family member 3 [ Homo sapiens (human) ]

    Gene ID: 152559, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PAQR3provided by HGNC
    Official Full Name
    progestin and adipoQ receptor family member 3provided by HGNC
    Primary source
    HGNC:HGNC:30130
    See related
    Ensembl:ENSG00000163291 MIM:614577; AllianceGenome:HGNC:30130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RKTG
    Summary
    This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
    Expression
    Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q21.21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (78887076..78939438, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82222838..82275056, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79833032..79860592, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:79696740-79697370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:79698003-79698633 Neighboring gene uncharacterized LOC124900722 Neighboring gene uncharacterized LOC105377299 Neighboring gene BMP2K divergent transcript Neighboring gene BMP2 inducible kinase Neighboring gene Sharpr-MPRA regulatory region 10702 Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15515 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene MPRA-validated peak5059 silencer Neighboring gene N-alpha-acetyltransferase 11, NatA catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:80169419-80169920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:80218690-80219258

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway. Wu YL, et al. J Clin Lab Anal, 2022 Sep. PMID 35870178, Free PMC Article
    2. Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway. Li H, et al. Eur J Pharmacol, 2018 Aug 5. PMID 29787774
    3. Aberrant promoter methylation of the PAQR3 gene is associated with prostate cancer. Lounglaithong K, et al. Pathol Res Pract, 2018 Jan. PMID 29122400
    4. PAQR3 overexpression suppresses the aggressive phenotype of esophageal squamous cell carcinoma cells via inhibition of ERK signaling. Bai G, et al. Biomed Pharmacother, 2017 Oct. PMID 28802234
    5. PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells. Zhou F, et al. Oncol Res, 2017 May 24. PMID 28548040, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
      Title: Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
    2. Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-beta/Smad pathway.
      Title: Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway.
    3. Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
      Title: Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
    4. PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
      Title: PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
    5. PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
      Title: PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
    6. Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
      Title: Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
    7. MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
      Title: MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
    8. PAQR3 might regulate the phosphorylation of FoxO1 and the expressions of GCK and LDLR through NF-kappaB pathway, thereby regulating the glucose and lipid metabolism disorders induced by insulin resistance.
      Title: PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway.
    9. Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation.
      Title: Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.
    10. Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway
      Title: Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to Golgi apparatus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    progestin and adipoQ receptor family member 3
    Names
    Raf kinase trapping to Golgi
    progestin and adipoQ receptor family member III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053104.1 RefSeqGene

      Range
      5001..32561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040202.2 → NP_001035292.1  progestin and adipoQ receptor family member 3 isoform 1

      See identical proteins and their annotated locations for NP_001035292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC093841, AY424281, BX648346, DA410845
      Consensus CDS
      CCDS34020.1
      UniProtKB/Swiss-Prot
      A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
      UniProtKB/TrEMBL
      F8W784
      Related
      ENSP00000421981.1, ENST00000512733.5
      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    2. NM_001350105.2 → NP_001337034.1  progestin and adipoQ receptor family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC093841
      Conserved Domains (1) summary
      cl03831
      Location:1 → 165
      HlyIII; Haemolysin-III related

    3. NM_001350106.2 → NP_001337035.1  progestin and adipoQ receptor family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC093841
      Conserved Domains (1) summary
      cl03831
      Location:1 → 165
      HlyIII; Haemolysin-III related

    RNA

    1. NR_146462.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841

    2. NR_146463.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841

    3. NR_146464.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841

    4. NR_146465.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      78887076..78939438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449645.1 → XP_047305601.1  progestin and adipoQ receptor family member 3 isoform X4

    2. XM_005262769.6 → XP_005262826.1  progestin and adipoQ receptor family member 3 isoform X2

      See identical proteins and their annotated locations for XP_005262826.1

      UniProtKB/TrEMBL
      F8W784
      Related
      ENSP00000344203.6, ENST00000342820.10
      Conserved Domains (1) summary
      cl03831
      Location:64 → 264
      HlyIII; Haemolysin-III related

    3. XM_024453910.2 → XP_024309678.1  progestin and adipoQ receptor family member 3 isoform X3

      Conserved Domains (1) summary
      cl03831
      Location:1 → 165
      HlyIII; Haemolysin-III related

    4. XM_047449643.1 → XP_047305599.1  progestin and adipoQ receptor family member 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
      Related
      ENSP00000425080.1, ENST00000511594.5

    RNA

    1. XR_938694.4 RNA Sequence

    2. XR_007096371.1 RNA Sequence

    3. XR_007096372.1 RNA Sequence

    4. XR_002959712.2 RNA Sequence

    5. XR_007096373.1 RNA Sequence

      Related
      ENST00000515853.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      82222838..82275056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348992.1 → XP_054204967.1  progestin and adipoQ receptor family member 3 isoform X4

    2. XM_054348991.1 → XP_054204966.1  progestin and adipoQ receptor family member 3 isoform X3

    3. XM_054348990.1 → XP_054204965.1  progestin and adipoQ receptor family member 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9

    RNA

    1. XR_008486927.1 RNA Sequence

    2. XR_008486926.1 RNA Sequence

    3. XR_008486925.1 RNA Sequence

    4. XR_008486928.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177453.2: Suppressed sequence

      Description
      NM_177453.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TCH7.2 GenPept UniProtKB/Swiss-Prot:Q6TCH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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