RBM3 RNA binding motif protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBM3provided by HGNC
Official Full Name: RNA binding motif protein 3provided by HGNC
Primary source: HGNC:HGNC:9900
See related: Ensembl:ENSG00000102317 MIM:300027; AllianceGenome:HGNC:9900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNPL; IS1-RNPL
Summary: This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 49.3), fat (RPKM 41.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (48574484..48581162)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (47983492..47990170)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (48432872..48439550)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling.
Title: RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling.
RBM3 is associated with acute lung injury in septic mice and patients via the NF-kappaB/NLRP3 pathway.
Title: RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
Influence of RRM, RGG and Potential Phosphorylated Sites in Cold-Inducible Protein RBM3 on its Subcellular Localization and Neuroprotective Effects.
Title: Influence of RRM, RGG and Potential Phosphorylated Sites in Cold-Inducible Protein RBM3 on its Subcellular Localization and Neuroprotective Effects.
RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury.
Title: RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury.
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Title: Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
RBM3 is an outstanding cold shock protein with multiple physiological functions beyond hypothermia.
Title: RBM3 is an outstanding cold shock protein with multiple physiological functions beyond hypothermia.
MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
Title: MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition.
Title: Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition.
PRR11 unveiled as a top candidate biomarker within the RBM3-regulated transcriptome in pancreatic cancer.
Title: PRR11 unveiled as a top candidate biomarker within the RBM3-regulated transcriptome in pancreatic cancer.
Characterization of RNA-Binding Motif 3 (RBM3) Protein Levels and Nuclear Architecture Changes in Aggressive and Recurrent Prostate Cancer.
Title: Characterization of RNA-Binding Motif 3 (RBM3) Protein Levels and Nuclear Architecture Changes in Aggressive and Recurrent Prostate Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2560 (e-PCR)
- UniSTS:37928

SHGC-35486 (e-PCR)
- UniSTS:81965

D8S2279 (e-PCR)
- UniSTS:473907

MARC_3075-3076:991936711:1 (e-PCR)
- UniSTS:230986

MARC_3075-3076:996678948:1 (e-PCR)
- UniSTS:230986

D15S1477 (e-PCR)
- UniSTS:474482

SHGC-31984 (e-PCR)
- UniSTS:77960

RH11301 (e-PCR)
- UniSTS:1418

STS-N40932 (e-PCR)
- UniSTS:32952

STS-AA037884 (e-PCR)
- UniSTS:54511

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal large subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
part_of large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 3

Names: RNA binding motif (RNP1, RRM) protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006743.5 → NP_006734.1 RNA-binding protein 3

See identical proteins and their annotated locations for NP_006734.1

Status: REVIEWED

Source sequence(s)

AC115618, BC006825

Consensus CDS

CCDS14301.1

UniProtKB/Swiss-Prot

P98179

Related

ENSP00000365950.3, ENST00000376759.8

Conserved Domains (1) summary

cd12449
Location:6 → 85

RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

48574484..48581162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

47983492..47990170

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001017430.1: Suppressed sequence

Description

NM_001017430.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_001017431.1: Suppressed sequence

Description

NM_001017431.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.