ADIPOR1 adiponectin receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADIPOR1provided by HGNC
Official Full Name: adiponectin receptor 1provided by HGNC
Primary source: HGNC:HGNC:24040
See related: Ensembl:ENSG00000159346 MIM:607945; AllianceGenome:HGNC:24040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A
Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
Expression: Ubiquitous expression in bone marrow (RPKM 58.7), placenta (RPKM 45.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (202940825..202958572, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (202203545..202221296, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (202909953..202927700, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of salusin-beta downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.
Title: Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.
Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
Title: Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease.
Title: Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease.
AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway.
Title: AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway.
Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.
Title: Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.
From diabetes to renal aging: the therapeutic potential of adiponectin.
Title: From diabetes to renal aging: the therapeutic potential of adiponectin.
Human adiponectin receptor AdipoR1 assumes closed and open structures.
Title: Human adiponectin receptor AdipoR1 assumes closed and open structures.
The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
Title: The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
Adiponectin is associated with cardio-metabolic traits in Mexican children.
Title: Adiponectin is associated with cardio-metabolic traits in Mexican children.
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
Title: Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.

Submit: New GeneRIF Correction See all GeneRIFs (195)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adipor1 (e-PCR), detects polymorphism
- UniSTS:471066

WI-18541 (e-PCR)
- UniSTS:33090

SHGC-34701 (e-PCR)
- UniSTS:37229

RH16184 (e-PCR)
- UniSTS:46496

G20811 (e-PCR)
- UniSTS:18112

A006H25 (e-PCR)
- UniSTS:18113

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables adiponectin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: adiponectin receptor protein 1

Names: progestin and adipoQ receptor family member 1; progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052860.1 RefSeqGene

Range

5261..22741

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001290553.2 → NP_001277482.1 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_001277482.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as R1T2) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AI251444, BC010743, DA523648

Consensus CDS

CCDS1430.1

UniProtKB/Swiss-Prot

B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
NM_001290557.1 → NP_001277486.1 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_001277486.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as R1T3) has an additional internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AC096632, AI251444, BC010743, BI597715

Consensus CDS

CCDS1430.1

UniProtKB/Swiss-Prot

B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
NM_001290629.1 → NP_001277558.1 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_001277558.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as R1T4) has an alternate 5' UTR, compared to variant 1. All variants encode the same protein.

Source sequence(s)

AI251444, BC010743, BI597715, BX461217

Consensus CDS

CCDS1430.1

UniProtKB/Swiss-Prot

B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related
NM_015999.6 → NP_057083.2 adiponectin receptor protein 1

See identical proteins and their annotated locations for NP_057083.2

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as R1T1) is a predominant transcript. All variants encode the same protein.

Source sequence(s)

AC096632, AI251444, BC010743

Consensus CDS

CCDS1430.1

UniProtKB/Swiss-Prot

B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

Related

ENSP00000341785.5, ENST00000340990.10

Conserved Domains (1) summary

pfam03006
Location:129 → 352

HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

202940825..202958572 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421959.1 → XP_047277915.1 adiponectin receptor protein 1 isoform X1

UniProtKB/Swiss-Prot

B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360
XM_024447427.2 → XP_024303195.1 adiponectin receptor protein 1 isoform X2

Conserved Domains (1) summary

pfam03006
Location:11 → 197

HlyIII; Haemolysin-III related

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

202203545..202221296 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336880.1 → XP_054192855.1 adiponectin receptor protein 1 isoform X1

UniProtKB/Swiss-Prot

B3KMB0, Q53HS7, Q53YY6, Q96A54, Q9Y360

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_046083.1: Suppressed sequence

Description

NR_046083.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.