Tlr12 toll-like receptor 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr12provided by MGI
Official Full Name: toll-like receptor 12provided by MGI
Primary source: MGI:MGI:3045221
See related: Ensembl:ENSMUSG00000062545 AllianceGenome:MGI:3045221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tlr11; Gm1365
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within defense response to protozoan. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human TLR12P (toll like receptor 12, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 4 D2.2; 4 62.08 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (128509239..128512412, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (128615446..128618619, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR11 or TLR12 silencing reduces parasite burden and increases IFN-gamma, but reduces IL-4, production indicating that TLR11 and TLR12 play a pro-leishmanial role.
Title: TLR11 or TLR12 silencing reduces Leishmania major infection.
Biochemical experiments revealed that TLR11 and TLR12 directly bind to Toxoplasma gondii profilin and are capable of forming a heterodimer complex.
Title: Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.
While parasite RNA and DNA activate innate immune responses via TLR7 and TLR9, TLR11 and TLR12 heterodimers are required for sensing and responding to Toxoplasma profilin infection.
Title: Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Title: Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections.
Title: Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 12

Names: toll-like receptor 11

NP_991392.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205823.2 → NP_991392.1 toll-like receptor 12 precursor

See identical proteins and their annotated locations for NP_991392.1

Status: VALIDATED

Source sequence(s)

AK137624

Consensus CDS

CCDS18673.1

UniProtKB/Swiss-Prot

Q6QNU9

UniProtKB/TrEMBL

A2RRZ9

Related

ENSMUSP00000074381.3, ENSMUST00000074829.4

Conserved Domains (4) summary

smart00255
Location:761 → 902

TIR; Toll - interleukin 1 - resistance

cd00116
Location:364 → 625

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:201 → 224

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:342 → 402

LRR_8; Leucine rich repeat