ANP32D acidic nuclear phosphoprotein 32 family member D [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANP32Dprovided by HGNC
Official Full Name: acidic nuclear phosphoprotein 32 family member Dprovided by HGNC
Primary source: HGNC:HGNC:16676
See related: Ensembl:ENSG00000139223 MIM:606878; AllianceGenome:HGNC:16676
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP32R2
Summary: Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 12q13.11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (48472559..48473622)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (48434409..48435472)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (48866342..48867405)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results highlight that certain malignancies with ANP32C/D overexpression or mutation might be specifically targeted using Hsp90 inhibitors.
Title: Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.
results provide independent evidence in support of a role for SENP1 in chronic mountain sickness in individuals of Quechua ancestry and suggest the SENP1 and ANP32D signatures of selection are in tight linkage disequilibrium (LD).
Title: Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480453

RH80847 (e-PCR)
- UniSTS:91353

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member D

Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member D; acidic nuclear phosphoprotein 32D; phosphoprotein 32-related protein 2; pp32 related 2; tumorigenic protein pp32r2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012404.3 → NP_036536.2 acidic leucine-rich nuclear phosphoprotein 32 family member D

See identical proteins and their annotated locations for NP_036536.2

Status: REVIEWED

Source sequence(s)

AC089987

Consensus CDS

CCDS31788.1

UniProtKB/Swiss-Prot

O95626, Q6NTC4

UniProtKB/TrEMBL

Q3KPI8

Related

ENSP00000266594.2, ENST00000266594.4

Conserved Domains (2) summary

sd00035
Location:90 → 113

LRR_NTF; leucine-rich repeat [structural motif]

pfam12799
Location:88 → 130

LRR_4; Leucine Rich repeats (2 copies)