PPDPF pancreatic progenitor cell differentiation and proliferation factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPDPFprovided by HGNC
Official Full Name: pancreatic progenitor cell differentiation and proliferation factorprovided by HGNC
Primary source: HGNC:HGNC:16142
See related: Ensembl:ENSG00000125534 AllianceGenome:HGNC:16142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: exdpf; C20orf149; dJ697K14.9
Summary: Predicted to be involved in cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon (RPKM 131.3), stomach (RPKM 115.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (63520741..63522206)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (65333433..65334898)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (62152094..62153559)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
Title: Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
Title: PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
Circ-FOXM1 upregulated the level of pancreatic progenitor cell differentiation and proliferation factor (PPDPF) and metastasis-associated in colon cancer 1 (MACC1) by sponging miR-1304-5p, thereby increasing the proliferation and invasion of non-small cell lung cancer cells.
Title: Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78083 (e-PCR)
- UniSTS:87071

RH66586 (e-PCR)
- UniSTS:89414

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pancreatic progenitor cell differentiation and proliferation factor

Names: exocrine differentiation and proliferation factor; pancreatic progenitor cell differentiation and proliferation factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353423.2 → NP_001340352.1 pancreatic progenitor cell differentiation and proliferation factor isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL121829

Conserved Domains (1) summary

pfam15060
Location:1 → 45

PPDFL; Differentiation and proliferation regulator
NM_024299.4 → NP_077275.1 pancreatic progenitor cell differentiation and proliferation factor isoform 1

See identical proteins and their annotated locations for NP_077275.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AL121829, BC002531, BP325433

Consensus CDS

CCDS13523.1

UniProtKB/Swiss-Prot

E1P5J2, Q4VXP1, Q9H3Y7, Q9H3Y8

UniProtKB/TrEMBL

X6R7I6

Related

ENSP00000359198.3, ENST00000370179.8

Conserved Domains (1) summary

pfam15060
Location:1 → 110

PPDFL; Differentiation and proliferation regulator

RNA

NR_148427.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AL121829, BF727015