U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CEACAM7 CEA cell adhesion molecule 7 [ Homo sapiens (human) ]

    Gene ID: 1087, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CEACAM7provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 7provided by HGNC
    Primary source
    HGNC:HGNC:1819
    See related
    Ensembl:ENSG00000007306 MIM:619160; AllianceGenome:HGNC:1819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGM2
    Summary
    This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Restricted expression toward colon (RPKM 448.6) See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    19q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41673303..41688270, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44492598..44507564, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42177231..42192199, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients. Pérez-García F, et al. J Microbiol Immunol Infect, 2022 Jun. PMID 34657826
    2. Structure of the N-terminal dimerization domain of CEACAM7. Bonsor DA, et al. Acta Crystallogr F Struct Biol Commun, 2015 Sep. PMID 26323304, Free PMC Article
    3. Distribution of carcinoembryonic antigen-related cellular adhesion molecules in human gingiva. Huynh-Torlakovic H, et al. Eur J Oral Sci, 2012 Oct. PMID 22984996
    4. Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA. Zhou J, et al. World J Surg Oncol, 2011 Dec 23. PMID 22195770, Free PMC Article
    5. CEACAM-7: a predictive marker for rectal cancer recurrence. Messick CA, et al. Surgery, 2010 May. PMID 20004437

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients.
      Title: CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients.
    2. CEACAM7 expression is significantly upregulated in human masticatory mucosa during wound healing
      Title: Human gingiva transcriptome during wound healing.
    3. crystal structure of the N-terminal dimerization domain of CEACAM has been determined at 1.47 A resolution
      Title: Structure of the N-terminal dimerization domain of CEACAM7.
    4. High CEACAM7 is associated with gastric carcinoma.
      Title: Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA.
    5. CEACAM-7 expression is significantly decreased in rectal cancer; a potential tumor marker
      Title: CEACAM-7: a predictive marker for rectal cancer recurrence.
    6. CGM2 RT-PCR assay provides no specific prognostic information and cannot be used as a decision criterion for adjuvant therapy after colorectal cancer surgery.
      Title: Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 7
    Names
    carcinoembryonic antigen CGM2
    carcinoembryonic antigen gene family member 2
    carcinoembryonic antigen related cell adhesion molecule 7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291485.2 → NP_001278414.1  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

      See identical proteins and their annotated locations for NP_001278414.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC243960, AK292213
      Consensus CDS
      CCDS12583.1
      UniProtKB/Swiss-Prot
      A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
      UniProtKB/TrEMBL
      B4DKM4
      Related
      ENSP00000385932.1, ENST00000401731.6
      Conserved Domains (2) summary
      cd05774
      Location:38 → 141
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:147 → 234
      Ig; Immunoglobulin domain

    2. NM_006890.5 → NP_008821.2  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

      See identical proteins and their annotated locations for NP_008821.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC243960, BC121132, DC345133
      Consensus CDS
      CCDS12583.1
      UniProtKB/Swiss-Prot
      A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
      UniProtKB/TrEMBL
      B4DKM4
      Related
      ENSP00000006724.3, ENST00000006724.7
      Conserved Domains (2) summary
      cd05774
      Location:38 → 141
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:147 → 234
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41673303..41688270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      4498..8698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44492598..44507564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14002.2 GenPept UniProtKB/Swiss-Prot:Q14002

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous