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    Mast2 microtubule associated serine/threonine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313819, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mast2provided by RGD
    Official Full Name
    microtubule associated serine/threonine kinase 2provided by RGD
    Primary source
    RGD:1304573
    See related
    Ensembl:ENSRNOG00000058476 AllianceGenome:RGD:1304573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and microtubule binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 117.8), Muscle (RPKM 101.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q35
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135013006..135152195, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129776293..129915502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135149336..135285337, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103122 Neighboring gene transfer RNA proline (anticodon AGG) 7 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 20 Neighboring gene intracisternal A particle-promoted polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis. Walden PD, et al. Biol Reprod, 1996 Nov. PMID 8902215
    2. A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Walden PD, et al. Mol Cell Biol, 1993 Dec. PMID 8246979, Free PMC Article
    3. Expression of the MAST family of serine/threonine kinases. Garland P, et al. Brain Res, 2008 Feb 21. PMID 18206861
    4. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Adey NB, et al. Cancer Res, 2000 Jan 1. PMID 10646847
    5. Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation. Zhou H, et al. J Immunol, 2004 Feb 15. PMID 14764729

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated serine/threonine-protein kinase 2
    NP_001101475.2
    XP_006238736.2
    XP_006238737.2
    XP_017448928.2
    XP_017448930.1
    XP_038966059.1
    XP_038966060.1
    XP_038966061.1
    XP_038966062.1
    XP_063143915.1
    XP_063143916.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108005.3 → NP_001101475.2  microtubule-associated serine/threonine-protein kinase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZMP0
      Related
      ENSRNOP00000079306.1, ENSRNOT00000114619.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135013006..135152195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238675.5 → XP_006238737.2  microtubule-associated serine/threonine-protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A6JZ72
      Conserved Domains (3) summary
      cd00992
      Location:1102 → 1183
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:512 → 791
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202 → 476
      DUF1908; Domain of unknown function (DUF1908)

    2. XM_006238674.5 → XP_006238736.2  microtubule-associated serine/threonine-protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A6JZ72
      Conserved Domains (3) summary
      cd00992
      Location:1109 → 1190
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:519 → 798
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202 → 483
      DUF1908; Domain of unknown function (DUF1908)

    3. XM_017593439.3 → XP_017448928.2  microtubule-associated serine/threonine-protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATY6, A6JZ72
      Related
      ENSRNOP00000097145.1
      Conserved Domains (3) summary
      cd00992
      Location:1109 → 1190
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:519 → 798
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202 → 483
      DUF1908; Domain of unknown function (DUF1908)

    4. XM_063287846.1 → XP_063143916.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

    5. XM_017593441.3 → XP_017448930.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      D3ZAR2

    6. XM_063287845.1 → XP_063143915.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

    7. XM_039110131.2 → XP_038966059.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZUU6, D3ZAR2
      Related
      ENSRNOP00000081749.1
      Conserved Domains (3) summary
      cd00992
      Location:1023 → 1104
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:433 → 712
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:116 → 397
      DUF1908; Domain of unknown function (DUF1908)

    8. XM_039110132.2 → XP_038966060.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      D3ZAR2
      Related
      ENSRNOP00000069015.2
      Conserved Domains (3) summary
      cd00992
      Location:958 → 1039
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368 → 647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51 → 332
      DUF1908; Domain of unknown function (DUF1908)

    9. XM_039110133.2 → XP_038966061.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

      UniProtKB/TrEMBL
      D3ZAR2
      Conserved Domains (3) summary
      cd00992
      Location:932 → 1013
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:342 → 621
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:25 → 306
      DUF1908; Domain of unknown function (DUF1908)

    10. XM_039110134.2 → XP_038966062.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

      UniProtKB/TrEMBL
      D3ZAR2
      Conserved Domains (3) summary
      cd00992
      Location:925 → 1006
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:335 → 614
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:25 → 299
      DUF1908; Domain of unknown function (DUF1908)
    Nucleotide Protein Strain
    Heading Accession and Version

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